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risperidone
generic
Black Box Warnings .
Dementia-Related Psychosis
not approved for dementia-related psychosis; incr. mortality risk in elderly pts on antipsychotic tx for dementia-related psychosis; most deaths due to cardiovascular or infectious events
Adult Dosing .
Dosage forms: TAB: 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, 4 mg; ODT: 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, 4 mg; SOL: 1 mg per mL; INJ: 12.5 mg per 2 mL, 25 mg per 2 mL, 37.5 mg per 2 mL, 50 mg per 2 mL
schizophrenia
- [PO route]
- Dose: 2-8 mg/day PO divided qd-bid; Start: 2 mg/day PO divided qd-bid, then incr. by 1-2 mg/day no more frequently than q24h; Max: 8 mg/day; Info: doses >6 mg/day rarely more effective, may incr. ADR risk; start 0.5 mg PO bid, titrate slowly in elderly pts; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; do not cut/chew ODT form
- [IM route]
- Dose: 25-50 mg IM q2wk; Start: 25 mg IM q2wk after establishing tolerability w/ PO risperidone, may incr. dose no more frequently than q4wk; Max: 50 mg IM q2wk; Info: overlap w/ PO risperidone or other PO antipsychotic x3wk; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
bipolar I disorder
- [acute manic/mixed]
- Dose: 1-6 mg/day PO divided qd-bid; Start: 2-3 mg PO qd, then may adjust dose by 1 mg/day no more frequently than q24h; Max: 6 mg/day; Info: for monotherapy or valproate or lithium adjunct; start 0.5 mg PO bid, titrate slowly in elderly pts; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; do not cut/chew ODT form
- [maintenance tx]
- Dose: 25-50 mg IM q2wk; Start: 25 mg IM q2wk after establishing tolerability w/ PO risperidone, may incr. dose no more frequently than q4wk; Max: 50 mg IM q2wk; Info: for monotherapy or valproate or lithium adjunct; overlap w/ PO risperidone or other PO antipsychotic x3wk; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
Tourette syndrome (off-label)
- [0.25-3 mg/day PO divided qd-bid]
- Start: 0.25-0.5 mg PO qd, then may incr. by up to 0.5 mg/day q4-5 days; Max: 6 mg/day; Info: periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; do not cut/chew ODT form
renal dosing
- [PO route, Tourette syndrome]
- renal impairment: not defined
- HD/PD: not defined
- [PO route, all other indications]
- CrCl <30: start 0.5 mg PO bid, may incr. by up to 0.5 mg PO bid until 1.5 mg bid, then may incr. dose no more frequently than qwk
- HD/PD: not defined
- [IM route]
- renal impairment: use PO form to titrate; start 0.5 mg PO bid x1wk, then may incr. to 2 mg/day PO divided qd-bid x1wk, if tolerating then may add 12.5-25 mg IM q2wk; Info: D/C PO form 3wk after 1st IM dose
- HD/PD: not defined
hepatic dosing
- [PO route, Tourette syndrome]
- hepatic impairment: not defined
- [PO route, all other indications]
- Child-Pugh Class C: start 0.5 mg PO bid, may incr. by up to 0.5 mg PO bid until 1.5 mg bid, then may incr. dose no more frequently than qwk
- [IM route]
- hepatic impairment: use PO form to titrate; start 0.5 mg PO bid x1wk, then may incr. to 2 mg/day PO divided qd-bid x1wk, if tolerating then may add 12.5-25 mg IM q2wk; Info: D/C PO form 3wk after 1st IM dose
Peds Dosing .
- Dosage forms: TAB: 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, 4 mg; ODT: 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, 4 mg; SOL: 1 mg per mL; INJ: 12.5 mg per 2 mL, 25 mg per 2 mL, 37.5 mg per 2 mL, 50 mg per 2 mL
schizophrenia
- [PO route, 13-17 yo]
- Dose: 1-6 mg/day PO divided qd-bid; Start: 0.5 mg PO qd, then incr. by 0.5-1 mg/day no more frequently than q24h; Max: 6 mg/day; Info: doses >3 mg/day rarely more effective, may incr. ADR risk; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; do not cut/chew ODT form
- [IM route, 13 yo and older (off-label)]
- Dose: 25-37.5 mg IM q2wk; Start: after establishing tolerability w/ PO risperidone, may incr. dose by 12.5 mg no more frequently than q4wk; Max: 50 mg IM q2wk; Info: for maintenance tx; overlap w/ PO risperidone x3wk; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
bipolar I disorder
- [acute manic/mixed, 10-17 yo]
- Dose: 0.5-6 mg/day PO divided qd-bid; Start: 0.5 mg PO qd, then incr. by 0.5-1 mg/day no more frequently than q24h; Max: 6 mg/day; Info: doses >2.5 mg/day rarely more effective, may incr. ADR risk; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; do not cut/chew ODT form
- [maintenance tx, 12 yo and older (off-label)]
- Dose: 25-37.5 mg IM q2wk; Start: 25 mg IM q2wk after establishing tolerability w/ PO risperidone, may incr. dose no more frequently than q4wk; Max: 50 mg IM q2wk; Info: overlap w/ PO risperidone x3wk; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
irritability, autistic disorder-associated
- [5-17 yo, 15-20 kg]
- Dose: 0.5-3 mg/day PO divided qd-bid; Start: 0.25 mg PO qd for at least 4 days, then incr. to 0.5 mg/day, then may adjust dose by 0.25 mg/day no more frequently than q2wk; Max: 3 mg/day; Info: periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; do not cut/chew ODT form
- [5-17 yo, >20 kg]
- Dose: 0.5-3 mg/day PO divided qd-bid; Start: 0.5 mg/day PO divided qd-bid for at least 4 days, then incr. to 1 mg/day, then may adjust dose by 0.5 mg/day no more frequently than q2wk; Max: 3 mg/day; Info: periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; do not cut/chew ODT form
Tourette syndrome (off-label)
- [6 yo and older]
- Dose: 0.25-3 mg/day PO divided qd-bid; Start: 0.25-0.5 mg PO qd, then may incr. by up to 0.5 mg/day q4-5 days; Max: 6 mg/day; Info: periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; do not cut/chew ODT form
renal dosing
- [PO route]
- renal impairment: decr. usual dose, amount not defined
- HD/PD: not defined
- [IM route]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: not defined
hepatic dosing
- [not defined]
- hepatic impairment: consider adult hepatic dosing for guidance