Entresto Sprinkle

Adult Dosing .

Adult dosing is currently unavailable or not applicable for this drug.

Peds Dosing .

Dosage forms:  PELLET: 6 mg/6 mg per cap, 15 mg/16 mg per cap

heart failure, symptomatic w/ left ventricular systolic dysfxn

[pts converting from usual dose ACE inhibitor or ARB tx, 1 yo and older, 13-18.9 kg]

Dose: 24 mg/24 mg PO bid; Start: 12 mg/12 mg PO bid x2wk, then 18 mg/18 mg PO bid x2wk, then 24 mg/24 mg PO bid; Info: must open cap, but do not chew/crush pellet; for pts converting from ACE inhibitor, start 36h after ACE inhibitor tx D/C

[pts converting from usual dose ACE inhibitor or ARB tx, 1 yo and older, 19-25.9 kg]

Dose: 30 mg/32 mg PO bid; Start: 18 mg/18 mg PO bid x2wk, then 24 mg/24 mg PO bid x2wk, then 30 mg/32 mg PO bid; Info: must open cap, but do not chew/crush pellet; for pts converting from ACE inhibitor, start 36h after ACE inhibitor tx D/C

[pts converting from usual dose ACE inhibitor or ARB tx, 1 yo and older, 26-33.9 kg]

Dose: 45 mg/48 mg PO bid; Start: 24 mg/24 mg PO bid x2wk, then 30 mg/32 mg PO bid x2wk, then 45 mg/48 mg PO bid; Info: must open cap, but do not chew/crush pellet; for pts converting from ACE inhibitor, start 36h after ACE inhibitor tx D/C

[pts converting from usual dose ACE inhibitor or ARB tx, 1 yo and older, 34-49.9 kg]

Dose: 60 mg/64 mg PO bid; Start: 30 mg/32 mg PO bid x2wk, then 45 mg/48 mg PO bid x2wk, then 60 mg/64 mg PO bid; Info: must open cap, but do not chew/crush pellet; for pts converting from ACE inhibitor, start 36h after ACE inhibitor tx D/C

[pts converting from low dose ACE inhibitor or ARB tx, 1 yo and older, 13-18.9 kg]

Dose: 24 mg/24 mg PO bid; Start: 6 mg/6 mg PO bid x2wk, then 12 mg/12 mg PO bid x2wk, then 18 mg/18 mg PO bid x2wk, then 24 mg/24 mg PO bid; Info: must open cap, but do not chew/crush pellet; for pts converting from ACE inhibitor, start 36h after ACE inhibitor tx D/C

[pts converting from low dose ACE inhibitor or ARB tx, 1 yo and older, 19-25.9 kg]

Dose: 30 mg/32 mg PO bid; Start: 9 mg/9 mg PO bid x2wk, then 18 mg/18 mg PO bid x2wk, then 24 mg/24 mg PO bid x2wk, then 30 mg/32 mg PO bid; Info: must open cap, but do not chew/crush pellet; may use oral suspension preparation from tab form for start dose; for pts converting from ACE inhibitor, start 36h after ACE inhibitor tx D/C

[pts converting from low dose ACE inhibitor or ARB tx, 1 yo and older, 26-33.9 kg]

Dose: 45 mg/48 mg PO bid; Start: 12 mg/12 mg PO bid x2wk, then 24 mg/24 mg PO bid x2wk, then 30 mg/32 mg PO bid x2wk, then 45 mg/48 mg PO bid; Info: must open cap, but do not chew/crush pellet; for pts converting from ACE inhibitor, start 36h after ACE inhibitor tx D/C

[pts converting from low dose ACE inhibitor or ARB tx, 1 yo and older, 34-49.9 kg]

Dose: 60 mg/64 mg PO bid; Start: 15 mg/16 mg PO bid x2wk, then 30 mg/32 mg PO bid x2wk, then 45 mg/48 mg PO bid x2wk, then 60 mg/64 mg PO bid; Info: must open cap, but do not chew/crush pellet; for pts converting from ACE inhibitor, start 36h after ACE inhibitor tx D/C

[pts currently not receiving ACE inhibitor or ARB tx, 1 yo and older, 13-18.9 kg]

Dose: 24 mg/24 mg PO bid; Start: 6 mg/6 mg PO bid x2wk, then 12 mg/12 mg PO bid x2wk, then 18 mg/18 mg PO bid x2wk, then 24 mg/24 mg PO bid; Info: must open cap, but do not chew/crush pellet

[pts currently not receiving ACE inhibitor or ARB tx, 1 yo and older, 19-25.9 kg]

Dose: 30 mg/32 mg PO bid; Start: 9 mg/9 mg PO bid x2wk, then 18 mg/18 mg PO bid x2wk, then 24 mg/24 mg PO bid x2wk, then 30 mg/32 mg PO bid; Info: must open cap, but do not chew/crush pellet; may use oral suspension preparation from tab form for start dose

[pts currently not receiving ACE inhibitor or ARB tx, 1 yo and older, 26-33.9 kg]

Dose: 45 mg/48 mg PO bid; Start: 12 mg/12 mg PO bid x2wk, then 24 mg/24 mg PO bid x2wk, then 30 mg/32 mg PO bid x2wk, then 45 mg/48 mg PO bid; Info: must open cap, but do not chew/crush pellet

[pts currently not receiving ACE inhibitor or ARB tx, 1 yo and older, 34-49.9 kg]

Dose: 60 mg/64 mg PO bid; Start: 15 mg/16 mg PO bid x2wk, then 30 mg/32 mg PO bid x2wk, then 45 mg/48 mg PO bid x2wk, then 60 mg/64 mg PO bid; Info: must open cap, but do not chew/crush pellet

renal dosing

[pts converting from usual dose ACE inhibitor or ARB tx]

eGFR <30: decr. usual start dose by 50%, then incr. dose q2wk following usual dose escalation

HD/PD: not defined

[all other pts]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[pts converting from usual dose ACE inhibitor or ARB tx]

Child-Pugh Class B: decr. usual start dose by 50%, then incr. dose q2wk following usual dose escalation; Child-Pugh Class C: avoid use

[all other pts]

Child-Pugh Class C: avoid use