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nefazodone
generic
Black Box Warnings .
Hepatic Failure
life-threatening hepatic failure cases; in US 1 case hepatic failure resulting in death or transplant per 250,000-300,000 pt-yr; avoid if active hepatic dz or elev. baseline LFT; advise pts to monitor hepatic impairment s/sx; D/C if clinical s/sx hepatic failure or AST or ALT >3x ULN, do not restart tx
Suicidality
incr. risk of suicidality in children, adolescents and young adults w/ major depressive or other psychiatric disorders esp. during 1st months of tx w/ antidepressants vs. placebo; weigh risk vs. benefit; in short-term studies of antidepressants vs. placebo, suicidality risk not incr. in pts >24 yo, and risk decr. in pts 65 yo and older; observe all pts for clinical worsening, suicidality, or unusual behavior changes; not approved for peds use
Adult Dosing .
Dosage forms: TAB: 50 mg, 100 mg, 150 mg, 200 mg, 250 mg
major depressive disorder
- [150-300 mg PO bid]
- Start: 100 mg PO bid, may incr. by 100-200 mg/day no more frequently than qwk; Max: 600 mg/day; Info: start 50 mg PO bid, consider slower titration in elderly or debilitated pts; taper dose gradually to D/C
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [see below]
- elev. LFTs/acute hepatic dz: contraindicated
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.