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nefazodone
generic
Black Box Warnings .
Hepatic Failure
life-threatening hepatic failure cases; in US 1 case hepatic failure resulting in death or transplant per 250,000-300,000 patient-years; avoid if active hepatic disease or elevated baseline LFT; advise patients to monitor hepatic impairment signs/symptoms; D/C if clinical signs/symptoms of hepatic failure or AST or ALT >3x ULN, do not restart tx
Suicidality
incr. risk of suicidality in children, adolescents and young adults with major depressive or other psychiatric disorders especially during 1st months of tx with antidepressants vs. placebo; weigh risk vs. benefit; in short-term studies of antidepressants vs. placebo, suicidality risk not incr. in patients >24 yo, and risk decr. in patients 65 yo and older; observe all patients for clinical worsening, suicidality, or unusual behavior changes; not approved for peds use
Adult Dosing .
Dosage forms: TAB: 50 mg, 100 mg, 150 mg, 200 mg, 250 mg
major depressive disorder
- [150-300 mg PO bid]
- Start: 100 mg PO bid, may incr. by 100-200 mg/day no more frequently than qwk; Max: 600 mg/day; Info: start 50 mg PO bid, consider slower titration in elderly or debilitated patients; taper dose gradually to D/C
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [see below]
- elevated LFTs/acute hepatic disease: contraindicated
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.