Sephience

Adult Dosing .

Dosage forms:  PWDR: 250 mg per pkt, 1000 mg per pkt

PKU

[7.5-60 mg/kg/dose PO qd]

Start: 60 mg/kg/dose PO qd; Max: 60 mg/kg/day; Info: adjust dose based on phenylalanine levels; give w/ food; D/C if no decr. in phenylalanine levels at max dose x2wk

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  PWDR: 250 mg per pkt, 1000 mg per pkt

PKU

[1-5 mo]

Dose: 7.5-60 mg/kg/dose PO qd; Start: 7.5 mg/kg/dose PO qd; Max: 60 mg/kg/day; Info: adjust dose based on phenylalanine levels; give w/ food; D/C if no decr. in phenylalanine levels at max dose x2wk

[6-11 mo]

Dose: 7.5-60 mg/kg/dose PO qd; Start: 15 mg/kg/dose PO qd; Max: 60 mg/kg/day; Info: adjust dose based on phenylalanine levels; give w/ food; D/C if no decr. in phenylalanine levels at max dose x2wk

[12-23 mo]

Dose: 7.5-60 mg/kg/dose PO qd; Start: 30 mg/kg/dose PO qd; Max: 60 mg/kg/day; Info: adjust dose based on phenylalanine levels; give w/ food; D/C if no decr. in phenylalanine levels at max dose x2wk

[2 yo and older]

Dose: 7.5-60 mg/kg/dose PO qd; Start: 60 mg/kg/dose PO qd; Max: 60 mg/kg/day; Info: adjust dose based on phenylalanine levels; give w/ food; D/C if no decr. in phenylalanine levels at max dose x2wk

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]