Awiqli (insulin icodec-abae)

Adult Dosing .

Dosage forms:  INJ (FlexTouch U-700 pen): 700 units per mL

Special Note

[drug name clarification]

Info: nonproprietary name = insulin icodec-abae

[strength clarification]

Info: FlexTouch U-700 pen delivers dose in 10 unit increments

[additional info]

Info: search Insulin Product Comparisons for comparison of onset, peak, duration, dosage form, and mixing compatibility

diabetes mellitus, type 2

[insulin-naive patients]

Dose: individualize dose SC qwk; Start: 70 units SC qwk; Max: 700 units/injection; Info: dose adjustment may be needed during pregnancy and/or immediately postpartum; onset 6-12h, no true peak, duration 7 days (long-acting basal insulin)

[conversion from daily basal insulin]

Dose: individualize dose SC qwk; Start: (1.5 x 7 x previous total daily basal insulin dose) SC qwk x1wk, then (7 x previous total daily basal insulin dose) SC qwk x1wk; Max: 700 units/injection; Info: give 1st weekly dose day after last daily basal insulin dose; round dose to nearest 10 units; dose adjustment may be needed during pregnancy and/or immediately postpartum; onset 6-12h, no true peak, duration 7 days (long-acting basal insulin)

renal dosing

[see below]

renal impairment: consider decr. usual start dose

HD: consider decr. usual start dose; no supplement after dialysis; PD: consider decr. usual start dose; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.