Ozempic Tablets

semaglutide

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Adult Dosing
Peds Dosing
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Black Box Warnings .

Thyroid C-cell Tumor Risk

contraindicated in patients with medullary thyroid carcinoma (MTC) history or family history, or in patients with multiple endocrine neoplasia syndrome type 2 (MEN 2); dose-related and duration-dependent incr. in thyroid C-cell tumor incidence observed in rodents, but human relevance unknown; uncertain value of routine serum calcitonin or thyroid ultrasound monitoring; advise patients of potential MTC risk and thyroid tumor symptoms (e.g., neck mass, dysphagia, dyspnea, persistent hoarseness)

Adult Dosing .

Dosage forms: TAB: 1.5 mg, 4 mg, 9 mg

Special Note

[prescribing info]: Info: see Wegovy for FDA-approved weight management dosing

[equivalency or interchangeability info]: Info: semaglutide 1.5 mg, 4 mg, 9 mg tabs not interchangeable with 3 mg, 7 mg, 14 mg tabs; do not substitute on a mg to mg basis

diabetes mellitus, type 2

[semaglutide-naive patients]: Dose: 4-9 mg PO qam; Start: 1.5 mg PO qam x30 days, then incr. dose to 4 mg PO qam; Info: may incr. dose to 9 mg PO qam after at least 30 days on 4 mg PO qam; give on empty stomach with up to 4 oz water >30min before food/drink/med; do not cut/crush/chew/dissolve tab

[conversion from semaglutide 7 mg PO qam]: Dose: 4 mg PO qam; Start: day after last 7 mg dose; Info: give on empty stomach with up to 4 oz water >30min before food/drink/med; do not cut/crush/chew/dissolve tab

[conversion from semaglutide 14 mg PO qam]: Dose: 9 mg PO qam; Start: day after last 14 mg dose; Info: give on empty stomach with up to 4 oz water >30min before food/drink/med; do not cut/crush/chew/dissolve tab

[conversion from semaglutide 0.5 mg SC qwk]: Dose: 4-9 mg PO qam; Start: 1wk after last injection; Info: give on empty stomach with up to 4 oz water >30min before food/drink/med; do not cut/crush/chew/dissolve tab

cardiovascular event risk reduction - DM type 2 patients at high risk

[semaglutide-naive patients]: Dose: 4-9 mg PO qam; Start: 1.5 mg PO qam x30 days, then incr. dose to 4 mg PO qam; Info: may incr. dose to 9 mg PO qam after at least 30 days on 4 mg PO qam if additional glycemic control needed; give on empty stomach with up to 4 oz water >30min before food/drink/med; do not cut/crush/chew/dissolve tab

[conversion from semaglutide 7 mg PO qam]: Dose: 4 mg PO qam; Start: day after last 7 mg dose; Info: give on empty stomach with up to 4 oz water >30min before food/drink/med; do not cut/crush/chew/dissolve tab

[conversion from semaglutide 14 mg PO qam]: Dose: 9 mg PO qam; Start: day after last 14 mg dose; Info: give on empty stomach with up to 4 oz water >30min before food/drink/med; do not cut/crush/chew/dissolve tab

[conversion from semaglutide 0.5 mg SC qwk]: Dose: 4-9 mg PO qam; Start: 1wk after last injection; Info: give on empty stomach with up to 4 oz water >30min before food/drink/med; do not cut/crush/chew/dissolve tab

renal dosing

[see below]: renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.

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