amantadine

Adult Dosing .

Dosage forms:  CAP: 100 mg; TAB: 100 mg; SOL: 50 mg per 5 mL

Special Note

[www.cdc.gov/flu]

Info: CDC recommends against use for influenza A in the US due to high level of amantadine resistance among currently circulating strains

influenza A (seasonal flu) tx

[100 mg PO bid x3-5 days]

Start: w/in 48h of sx onset; Info: not recommended per CDC and IDSA guidelines; give 100 mg PO qd in elderly pts; consider lower doses in debilitated pts; D/C w/in 24-48h of sx resolution

influenza A (seasonal flu) prophylaxis

[100 mg PO bid]

Start: prior to or immed. upon exposure; Info: not recommended per CDC and IDSA guidelines; give 100 mg PO qd in elderly pts; consider lower doses in debilitated pts; taper dose gradually to D/C

extrapyramidal sx

[100 mg PO bid]

Max: 300 mg/day; Info: taper dose gradually to D/C

parkinsonism

[100 mg PO bid]

Max: 400 mg/day; Info: start 100 mg qd if taking other Parkinson dz tx or debilitated; may titrate dose qwk; taper dose gradually to D/C

neuroleptic malignant syndrome (off-label)

[200-400 mg/day PO divided bid-tid]

renal dosing

[adjust dose amount, frequency]

CrCl 30-50: 200 mg x1, then 100 mg qd; CrCl 15-29: 200 mg x1, then 100 mg q48h; CrCl <15: 200 mg q7 days

HD: 200 mg q7 days; no supplement after dialysis; PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  CAP: 100 mg; TAB: 100 mg; SOL: 50 mg per 5 mL

Special Note

[www.cdc.gov/flu]

Info: CDC recommends against use for influenza A in the US due to high level of amantadine resistance among currently circulating strains

influenza A (seasonal flu) tx

[1-9 yo]

Dose: 5 mg/kg/day PO divided bid x3-5 days; Start: w/in 48h of sx onset; Max: 150 mg/day; Info: not recommended per CDC and IDSA guidelines; D/C w/in 24-48h of sx resolution

[10 yo and older]

Dose: 100 mg PO bid x3-5 days; Start: w/in 48h of sx onset; Max: 200 mg/day; Alt: 5 mg/kg/day PO divided bid x3-5 days; Info: not recommended per CDC and IDSA guidelines; D/C w/in 24-48h of sx resolution; taper dose gradually to D/C

influenza A (seasonal flu) prophylaxis

[1-9 yo]

Dose: 5 mg/kg/day PO divided bid; Start: prior to or immed. upon exposure; Max: 150 mg/day; Info: not recommended per CDC and IDSA guidelines; taper dose gradually to D/C

[10 yo and older]

Dose: 100 mg PO bid; Start: prior to or immed. upon exposure; Max: 200 mg/day; Alt: 5 mg/kg/day PO divided bid; Info: not recommended per CDC and IDSA guidelines; taper dose gradually to D/C

renal dosing

[adjust dose amount, frequency]

CrCl 30-50: give 50% usual divided dose q24h; CrCl 15-29: give 50% usual divided dose q48-72h; CrCl <15: give usual divided dose q7 days

HD: give usual divided dose q7 days; no supplement after dialysis; PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised