sildenafil

Adult Dosing .

Dosage forms:  TAB: 20 mg, 25 mg, 50 mg, 100 mg; SUSP: 10 mg per mL; INJ: various

erectile dysfxn

[25-100 mg PO x1]

Start: 50 mg PO x1; Max: 100 mg/dose up to 1 dose/day; Info: give 0.5-4h before sexual activity; consider starting 25 mg PO x1 in pts >65 yo

pulmonary arterial HTN

[20 mg PO tid]

Max: 240 mg/day PO; Alt: 10 mg IV q8h; Info: space doses 4-6h apart

renal dosing

[erectile dysfxn]

CrCl <30: consider starting 25 mg x1

HD/PD: not defined

[pulmonary arterial HTN]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[erectile dysfxn]

hepatic impairment/cirrhosis: consider starting 25 mg x1

[pulmonary arterial HTN]

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

Peds Dosing .

Dosage forms:  TAB: 20 mg; SUSP: 10 mg per mL

pulmonary arterial HTN

[<1 yo (off-label)]

Dose: 0.5-1 mg/kg/dose PO tid; Info: space doses 4-6h apart

[1-17 yo, <20 kg]

Dose: 10 mg PO tid; Info: space doses 4-6h apart

[1-17 yo, 20-45 kg]

Dose: 20 mg PO tid; Info: space doses 4-6h apart

[1-17 yo, >45 kg]

Dose: 20 mg PO tid; Max: 120 mg/day; Info: space doses 4-6h apart

persistent pulmonary HTN of newborn, refractory (off-label)

[<1 mo]

Dose: 0.5-1 mg/kg/dose PO tid; Info: for adjunct tx; space doses 4-6h apart; delay tx start in extremely premature infants until retinal vascularization established

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined