Select a medication above to begin.
bupropion hydrochloride
generic
Black Box Warnings .
Suicidality
incr. suicidality risk in children, adolescents, and young adults w/ major depressive or other psychiatric disorders; weigh risk vs. benefit; in short-term studies of antidepressants vs. placebo, suicidality risk not incr. in pts >24 yo, and risk decr. in pts 65 yo and older; depression and certain other psychiatric disorders themselves assoc. w/ incr. suicide risk; observe all pts for clinical worsening, suicidality, or unusual behavior changes; advise families and caregivers of need for close observation and communication w/ prescriber
Adult Dosing .
Dosage forms: TAB: 75 mg, 100 mg; ER TAB (12h): 100 mg, 150 mg, 200 mg; ER TAB (24h): 150 mg, 300 mg
major depressive disorder
- [immediate-release form]
- Dose: 100 mg PO tid; Start: 100 mg PO bid, may incr. to 100 mg PO tid after 3 days; Max: 150 mg/dose up to 450 mg/day; Info: separate doses by at least 6h
- [12h extended-release form]
- Dose: 150 mg ER PO bid; Start: 150 mg ER PO qam, may incr. to 150 mg ER PO bid after 3 days; Max: 200 mg/dose ER up to 400 mg/day ER; Info: separate doses by at least 8h; do not cut/crush/chew ER form
- [24h extended-release form]
- Dose: 300 mg ER PO qam; Start: 150 mg ER PO qam, may incr. to 300 mg ER PO qam after 4 days; Max: 450 mg/day ER; Info: do not cut/crush/chew ER form
seasonal affective disorder
- [24h extended-release form]
- Dose: 300 mg ER PO qam x4-6mo/year; Start: 150 mg ER PO qam, may incr. to 300 mg ER PO qam after 7 days; Max: 300 mg/day ER; Info: begin tx in Sep-Nov, continue through early spring; decr. dose to 150 mg/day x2wk to D/C; do not cut/crush/chew ER form
smoking cessation
- [12h extended-release form]
- Dose: 150 mg ER PO bid x7-12wk; Start: 150 mg ER PO qd, incr. to 150 mg ER PO bid after 3 days; Max: 300 mg/day ER; Info: separate doses by at least 8h; last dose no later than 6pm; stop smoking after 5-7 days of tx; do not cut/crush/chew ER form
ADHD (off-label)
- [12h extended-release form]
- Dose: 200 mg ER PO qam, 100 mg ER PO qpm; Start: 100 mg ER PO qam, may incr. by 100 mg/day qwk, divide dose bid; Max: 400 mg/day ER; Info: separate doses by at least 8h; do not cut/crush/chew ER form
- [24h extended-release form]
- Dose: 300 mg ER PO qam; Start: 150 mg ER PO qam, may incr. to 300 mg ER PO qam after 7 days; Max: 450 mg/day ER; Info: do not cut/crush/chew ER form
renal dosing
- [see below]
- renal impairment: consider decr. usual dose and/or frequency; Info: ER form cannot be cut, consider IR form for dose adjustments
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class A: consider decr. usual dose and/or frequency; Child-Pugh Class B or C: max 75 mg/day, 100 mg ER qd, or 150 mg ER q48h
Peds Dosing .
- Dosage forms: TAB: 75 mg, 100 mg; ER TAB (12h): 100 mg, 150 mg, 200 mg; ER TAB (24h): 150 mg, 300 mg
major depressive disorder (off-label)
- [immediate-release form, 8 yo and older]
- Dose: 100-300 mg/day PO divided bid-tid; Start: 37.5 mg PO bid, may incr. dose q1-2wk; Max: 400 mg/day; Info: not 1st line tx; separate doses by at least 6h
- [12h extended-release form, 11 yo and older]
- Dose: 3-6 mg/kg/day ER PO divided bid; Start: 2 mg/kg/dose ER up to 100 mg ER PO qam, may incr. by up to 1 mg/kg/day ER q2-3wk; Max: 150 mg/dose ER; Info: not 1st line tx; separate doses by at least 8h; do not cut/crush/chew ER form
- [24h extended-release form, 12 yo and older]
- Dose: 150-300 mg ER PO qam; Start: 150 mg ER PO qam, may incr. to 300 mg ER PO qam after 2wk; Info: not 1st line tx; do not cut/crush/chew ER form
ADHD (off-label)
- [immediate-release form, 6 yo and older]
- Dose: 1.4-6 mg/kg/day PO divided bid-tid; Start: 1.5-3 mg/kg/day PO divided bid, may incr. dose after at least 3 days; Max: 150 mg/dose, 6 mg/kg/day up to 300 mg/day; Info: separate doses by at least 6h
- [12h extended-release form, 11 yo and older]
- Dose: 3-6 mg/kg/day ER PO divided bid; Start: 2 mg/kg/dose ER up to 100 mg ER PO qam, may incr. by up to 1 mg/kg/day ER q2-3wk; Max: 150 mg/dose ER; Info: separate doses by at least 8h; do not cut/crush/chew ER form
- [24h extended-release form, 12 yo and older]
- Dose: 150-300 mg ER PO qam; Start: 150 mg ER PO qam, may incr. to 300 mg ER PO qam after 2wk; Info: do not cut/crush/chew ER form
smoking cessation (off-label)
- [12h extended-release form, 14 yo and older, >40.5 kg]
- Dose: 150 mg ER PO bid x7-12wk; Start: 150 mg ER PO qd, incr. to 150 mg ER PO bid after 3 days; Max: 300 mg/day ER; Info: separate doses by at least 8h; last dose no later than 6pm; stop smoking after 5-7 days of tx; do not cut/crush/chew ER form
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: not defined
hepatic dosing
- [not defined]
- hepatic impairment: consider adult hepatic dosing for guidance