Select a medication above to begin.
sertraline
generic
Black Box Warnings .
Suicidality
antidepressants incr. suicidality risk in peds and young adult patients in short-term studies; monitor closely for clinical worsening and suicidality; advise families and caregivers of need for close observation and communication with prescriber
Adult Dosing .
Dosage forms: CAP: 150 mg, 200 mg; TAB: 25 mg, 50 mg, 100 mg; SOL: 20 mg per mL
major depressive disorder
- [50-200 mg PO qd]
- Start: 50 mg PO qd, may incr. by 25-50 mg/day qwk; Max: 200 mg/day; Info: taper dose gradually to D/C; do not open cap
obsessive-compulsive disorder
- [50-200 mg PO qd]
- Start: 50 mg PO qd, may incr. by 25-50 mg/day qwk; Max: 200 mg/day; Info: taper dose gradually to D/C; do not open cap
panic disorder
- [50-200 mg PO qd]
- Start: 25 mg PO qd, may incr. by 25-50 mg/day qwk; Max: 200 mg/day; Info: taper dose gradually to D/C; do not open cap
post-traumatic stress disorder
- [50-200 mg PO qd]
- Start: 25 mg PO qd, may incr. by 25-50 mg/day qwk; Max: 200 mg/day; Info: taper dose gradually to D/C; do not open cap
premenstrual dysphoric disorder
- [daily dosing]
- Dose: 50-150 mg PO qd; Start: 50 mg PO qd, may incr. by 50 mg/day with each menstrual cycle; Max: 150 mg/day; Info: taper dose gradually to D/C; do not open cap
- [luteal phase dosing]
- Dose: 50-100 mg PO qd during luteal phase; Start: 50 mg PO qd during luteal phase; Max: 100 mg/day; Info: if inadequate response with 50 mg PO qd, may give 50 mg PO qd x3 days, then incr. to 100 mg PO qd with each luteal phase dosing cycle
social anxiety disorder
- [50-200 mg PO qd]
- Start: 25 mg PO qd, may incr. by 25-50 mg/day qwk; Max: 200 mg/day; Info: taper dose gradually to D/C; do not open cap
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- Child-Pugh Class A: decr. usual dose by 50%; Child-Pugh Class B or C: avoid use
Peds Dosing .
- Dosage forms: CAP: 150 mg, 200 mg; TAB: 25 mg, 50 mg, 100 mg; SOL: 20 mg per mL
obsessive-compulsive disorder
- [6-12 yo]
- Dose: 50-200 mg PO qd; Start: 25 mg PO qd, may incr. by 25-50 mg/day qwk; Max: 200 mg/day; Info: taper dose gradually to D/C; do not open cap
- [13-17 yo]
- Dose: 50-200 mg PO qd; Start: 50 mg PO qd, may incr. by 25-50 mg/day qwk; Max: 200 mg/day; Info: taper dose gradually to D/C; do not open cap
major depressive disorder (off-label)
- [10 yo and older]
- Dose: 25-200 mg PO qd; Start: 25 mg PO qd, may incr. by 12.5-25 mg/day qwk; Max: 200 mg/day; Info: taper dose gradually to D/C; do not open cap
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- Child-Pugh Class A: decr. usual dose by 50%; Child-Pugh Class B or C: avoid use