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ibutilide
generic
Black Box Warnings .
Appropriate Use
administer w/ continuous ECG monitoring by personnel trained in acute ventricular arrhythmia identification and tx; weigh benefit vs. proarrhythmic risk; pts w/ atrial fibrillation >2-3 days need adequate anticoagulation >2wk prior to use
Proarrhythmic Effects
may cause potentially fatal arrhythmias incl. sustained polymorphic ventricular tachycardia w/ or w/o QT prolongation/torsades de pointes
Adult Dosing .
Dosage forms: INJ
atrial fibrillation/flutter cardioversion
- [<60 kg]
- Dose: 0.01 mg/kg/dose IV x1; Info: may repeat dose x1 after 10min if no response
- [>60 kg]
- Dose: 1 mg IV x1; Info: may repeat dose x1 after 10min if no response
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [no adjustment]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.