eptifibatide

Adult Dosing .

Dosage forms:  INJ

acute coronary syndrome

[2 mcg/kg/min IV]

Start: 180 mcg/kg/dose up to 22.6 mg IV x1; Max: 15 mg/h infusion; Info: give until discharge or CABG surgery up to 72h duration; if undergoing PCI, give until discharge or x18-24h post-procedure up to 96h duration; may use with aspirin, heparin

PCI

[2 mcg/kg/min IV]

Start: 180 mcg/kg/dose IV up to 22.6 mg x1 before procedure; Max: 15 mg/h infusion; Info: repeat bolus dose x1 10min after initial dose; give infusion for at least 12h up to discharge or x18-24h post-procedure; may use with aspirin, heparin

renal dosing

[acute coronary syndrome]

CrCl <50: 180 mcg/kg/dose IV up to 22.6 mg x1, then 1 mcg/kg/min, max 7.5 mg/h

HD/PD: contraindicated

[PCI]

CrCl <50: 180 mcg/kg/dose IV up to 22.6 mg x1, then 1 mcg/kg/min, max 7.5 mg/h; Info: repeat bolus dose x1 10min after initial dose

HD/PD: contraindicated

hepatic dosing

[not defined]

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.