granisetron

Adult Dosing .

Dosage forms:  TAB: 1 mg; INJ: various

nausea/vomiting prevention, chemo-related

[IV route, highly-emetogenic parenteral chemo]

Dose: 10 mcg/kg/dose IV x1 on day 1; Start: w/in 30min before chemo; Max: 1 mg/dose; Info: part of multi-drug regimen; search 'CINV' for epocrates Chemo-Induced Nausea & Vomiting in Adults decision tool

[IV route, moderately-emetogenic parenteral chemo]

Dose: 10 mcg/kg/dose IV x1 on day 1, then may give 10 mcg/kg/dose IV qd on days 2-3; Start: w/in 30min before chemo; Max: 1 mg/dose; Info: part of multi-drug regimen; search 'CINV' for epocrates Chemo-Induced Nausea & Vomiting in Adults decision tool

[PO route, highly-emetogenic parenteral chemo]

Dose: 2 mg PO x1 on day 1; Start: up to 1h before chemo; Info: part of multi-drug regimen; search 'CINV' for epocrates Chemo-Induced Nausea & Vomiting in Adults decision tool

[PO route, moderately-emetogenic parenteral chemo]

Dose: 2 mg PO x1 on day 1, then may give 1-2 mg PO qd on days 2-3; Start: up to 1h before chemo; Info: part of multi-drug regimen; search 'CINV' for epocrates Chemo-Induced Nausea & Vomiting in Adults decision tool

[PO route, low-emetogenic parenteral chemo (off-label)]

Dose: 1-2 mg PO x1; Start: up to 1h before chemo; Info: may repeat 1-2 mg PO qd for multi-day chemo; search 'CINV' for epocrates Chemo-Induced Nausea & Vomiting in Adults decision tool

[PO route, oral chemo (off-label)]

Dose: 1-2 mg PO qd; Start: up to 1h before chemo; Info: may give prn if minimally- or low-emetogenic oral chemo; search 'CINV' for epocrates Chemo-Induced Nausea & Vomiting in Adults decision tool

refractory nausea/vomiting, chemo-related (off-label)

[IV route]

Dose: 10 mcg/kg/dose IV qd; Max: 1 mg/dose; Info: search 'CINV' for epocrates Chemo-Induced Nausea & Vomiting in Adults decision tool

[PO route]

Dose: 1-2 mg PO qd; Alt: 1 mg PO bid; Info: search 'CINV' for epocrates Chemo-Induced Nausea & Vomiting in Adults decision tool

nausea/vomiting prevention, XRT-related

[2 mg PO qd]

Start: w/in 1h of XRT

nausea/vomiting, postop

[1 mg IV x1]

Start: before anesthesia induction or reversal for prophylaxis or postop for tx

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  INJ

nausea/vomiting prevention, chemo-related

[2 yo and older]

Dose: 10 mcg/kg/dose IV x1; Start: w/in 30min before chemo

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[no adjustment]