Thrombate III

Adult Dosing .

Dosage forms:  INJ

thromboembolism tx, hereditary antithrombin deficiency

[individualize dose (loading dose x 0.6 units) IV q24h x2-8 days]

Start: (120% - baseline % x body weight (kg)/1.4% units) IV x1 to target AT level 120% of normal, then titrate based on trough level of preceding dose (target % - trough % x body weight (kg)/1.4% units); Info: target AT level 80-120% of normal for maintenance dose

thromboembolism prophylaxis, hereditary antithrombin deficiency

[individualize dose (loading dose x 0.6 units) IV q24h x2-8 days]

Start: (120% - baseline % x body weight (kg)/1.4% units) IV x1 to target AT level 120% of normal, then titrate based on trough level of preceding dose (target % - trough % x body weight (kg)/1.4% units); Info: includes peri-operative or peri-partum settings; target AT level 80-120% of normal for maintenance dose

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

thromboembolism tx, hereditary antithrombin deficiency

[individualize dose (loading dose x 0.6 units) IV q24h x2-8 days]

Start: (120% - baseline % x body weight (kg)/1.4% units) IV x1 to target AT level 120% of normal, then titrate based on trough level of preceding dose (target % - trough % x body weight (kg)/1.4% units); Info: target AT level 80-120% of normal for maintenance dose

thromboembolism prophylaxis, hereditary antithrombin deficiency

[individualize dose (loading dose x 0.6 units) IV q24h x2-8 days]

Start: (120% - baseline % x body weight (kg)/1.4% units) IV x1 to target AT level 120% of normal, then titrate based on trough level of preceding dose (target % - trough % x body weight (kg)/1.4% units); Info: includes peri-operative settings; target AT level 80-120% of normal for maintenance dose

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]