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alprostadil
generic
Black Box Warnings .
Apnea
10-12% of neonates with congenital heart defects experience apnea with alprostadil; most common if birth wt <2 kg, typically within 1st hour of infusion; monitor respiratory status throughout tx and use where ventilatory assistance immediately available
Adult Dosing .
Adult dosing is currently unavailable or not applicable for this drug.
Peds Dosing .
- Dosage forms: INJ
patent ductus arteriosus
- [0.05-0.4 mcg/kg/min IV]
- Start: 0.05-0.1 mcg/kg/min IV; Max: 0.4 mcg/kg/min; Info: use lowest effective dose, shortest effective tx duration
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [not defined]