nalmefene

Adult Dosing .

Dosage forms:  INJ

opioid overdose

[0.5 mg/70 kg/dose IV/IM/SC x1]

Max: 1.5 mg/70 kg/total dose; Info: may give additional 1 mg/70 kg/dose IV/IM/SC x1 after 2-5min; if opioid dependency suspected, give 0.1 mg/70 kg/dose IV/IM/SC x1 as initial challenge dose, max 1.6 mg/70 kg/total dose

opioid reversal

[0.5 mg/70 kg/dose IV/IM/SC x1]

Max: 1.5 mg/70 kg/total dose; Info: may give additional 1 mg/70 kg/dose IV/IM/SC x1 after 2-5min; if opioid dependency suspected, give 0.1 mg/70 kg/dose IV/IM/SC x1 as initial challenge dose, max 1.6 mg/70 kg/total dose

renal dosing

[see below]

renal failure: give usual dose slowly over 1min

HD/PD: give usual dose slowly over 1min; no supplement

hepatic dosing

[no adjustment]

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.