Select a medication above to begin.
ribavirin
generic
Black Box Warnings .
Monotherapy Not Indicated
monotherapy ineffective for chronic HCV and should be avoided
Hemolytic Anemia
primary clinical toxicity; may worsen cardiac dz and lead to fatal and nonfatal MI; avoid use in pts w/ significant or unstable cardiac dz
Teratogenic/Embryocidal
teratogenic/embryocidal effects in all animal species; multiple dose half-life 12 days and may persist in non-plasma compartments <6mo; contraindicated in pregnant women and their male partners; avoid pregnancy during and for 6mo after tx in female pts and female partners of male pts; use 2 forms reliable contraception during and for 6mo after tx
Adult Dosing .
Dosage forms: CAP: 200 mg; TAB: 200 mg
hepatitis C infection, chronic
- [direct-acting antiviral combo tx, various genotypes (off-label)]
- Dose: 400-700 mg PO bid; Alt: 600-1000 mg PO qd; Info: dose may depend on wt; see direct-acting antiviral pkg inserts for ribavirin dosing and duration; refer to AASLD/IDSA hepatitis C guidelines; do not open/crush/chew cap; give w/ food
renal dosing
- [capsules]
- CrCl <50: contraindicated per pkg insert; Alt: 200 mg q48h alternate w/ 400 mg q48h if CrCl 30-50; 200 mg qd if CrCl <30
- HD: 200 mg qd, on dialysis days admin. after dialysis; no supplement; PD: not defined
- [tablets]
- CrCl 30-50: 200 mg q48h alternate w/ 400 mg q48h; CrCl <30: 200 mg qd
- HD: 200 mg qd, on dialysis days admin. after dialysis; no supplement; PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class B or C or autoimmune hepatitis: contraindicated
Peds Dosing .
- Dosage forms: CAP: 200 mg; TAB: 200 mg
hepatitis C infection, chronic
- [sofosbuvir-containing combo tx, 3 yo and older, <47 kg (off-label)]
- Dose: 15 mg/kg/day PO divided bid x12-24wk; Info: duration depends on genotype, other direct-acting antivirals used; do not open/crush/chew cap; give w/ food
- [sofosbuvir-containing combo tx, 3 yo and older, 47-49 kg (off-label)]
- Dose: 600 mg/day PO divided bid x12-24wk; Info: duration depends on genotype, other direct-acting antivirals used; do not open/crush/chew cap; give w/ food
- [sofosbuvir-containing combo tx, 3 yo and older, 50-65 kg (off-label)]
- Dose: 800 mg/day PO divided bid x12-24wk; Info: duration depends on genotype, other direct-acting antivirals used; do not open/crush/chew cap; give w/ food
- [sofosbuvir-containing combo tx, 3 yo and older, 66-80 kg (off-label)]
- Dose: 1000 mg/day PO divided bid x12-24wk; Info: duration depends on genotype, other direct-acting antivirals used; do not open/crush/chew cap; give w/ food
- [sofosbuvir-containing combo tx, 3 yo and older, >80 kg (off-label)]
- Dose: 1200 mg/day PO divided bid x12-24wk; Info: duration depends on genotype, other direct-acting antivirals used; do not open/crush/chew cap; give w/ food
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: consider adult renal dosing for guidance
hepatic dosing
- [see below]
- Child-Pugh Class B or C or autoimmune hepatitis: contraindicated