minocycline

Adult Dosing .

Dosage forms:  CAP: 50 mg, 75 mg, 100 mg; TAB: 50 mg, 75 mg, 100 mg; ER TAB: 45 mg, 55 mg, 65 mg, 80 mg, 90 mg, 105 mg, 115 mg, 135 mg

infections, bacterial

[100 mg PO bid]

Start: 200 mg PO x1; Max: 400 mg/day; Alt: start 100-200 mg PO x1, then 50 mg PO qid; Info: duration varies w/ infection type, severity; give w/ adequate fluid to decr. esophageal irritation/ulceration

acne vulgaris

[mod-severe, non-nodular dz]

Dose: 1 mg/kg/dose ER PO qd x12wk; Info: for inflammatory lesions only; use closest ER tab strength; give ER tab w/ food to decr. esophageal irritation/ulceration; do not cut/crush/chew ER tab

[severe dz]

Dose: 50-100 mg PO qd; Start: 50-100 mg PO bid x2-3mo; Info: for adjunct tx; give w/ adequate fluid to decr. esophageal irritation/ulceration

leprosy (Hansen dz), multibacillary (off-label)

[pts who cannot take clofazimine]

Dose: 100 mg PO qd x12mo; Info: not 1st-line agent; part of multi-drug regimen; give w/ adequate fluid to decr. esophageal irritation/ulceration; may continue tx beyond 12mo in refractory cases

[pts who cannot take rifampin]

Dose: 100 mg PO qd x24mo; Info: not 1st-line agent; part of multi-drug regimen; give w/ adequate fluid to decr. esophageal irritation/ulceration; may continue tx beyond 24mo in refractory cases

leprosy (Hansen dz), paucibacillary (off-label)

[pts who cannot take rifampin]

Dose: 100 mg PO qd x24mo; Info: not 1st-line agent; part of multi-drug regimen; give w/ adequate fluid to decr. esophageal irritation/ulceration; may continue tx beyond 24mo in refractory cases

renal dosing

[IR form]

renal impairment: decr. usual dose and/or frequency, amount not defined, max 200 mg/day

HD/PD: not defined

[ER form]

renal impairment: decr. usual dose and/or frequency, amount not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  CAP: 50 mg, 75 mg, 100 mg; TAB: 50 mg, 75 mg, 100 mg; ER TAB: 45 mg, 55mg, 65 mg, 80 mg, 90 mg, 105 mg, 115 mg, 135 mg

infections, bacterial

[>8 yo]

Dose: 2 mg/kg/dose PO bid; Start: 4 mg/kg/dose PO x1; Max: 200 mg/day; Info: duration varies w/ infection type, severity; give w/ adequate fluid to decr. esophageal irritation/ulceration

acne vulgaris

[mod-severe, non-nodular dz, 12 yo and older]

Dose: 1 mg/kg/dose ER PO qd x12wk; Info: for inflammatory lesions only; use closest ER tab strength; give ER tab w/ food to decr. esophageal irritation/ulceration; do not cut/crush/chew ER tab

[severe dz, >8 yo]

Dose: 50-100 mg PO qd; Start: 50-100 mg PO bid x2-3mo; Info: for adjunct tx; give w/ adequate fluid to decr. esophageal irritation/ulceration

leprosy (Hansen dz), multibacillary (off-label)

[15 yo and older, pts who cannot take clofazimine]

Dose: 100 mg PO qd x12mo; Info: not 1st-line agent; part of multi-drug regimen; give w/ adequate fluid to decr. esophageal irritation/ulceration; may continue tx beyond 12mo in refractory cases

[15 yo and older, pts who cannot take rifampin]

Dose: 100 mg PO qd x24mo; Info: not 1st-line agent; part of multi-drug regimen; give w/ adequate fluid to decr. esophageal irritation/ulceration; may continue tx beyond 24mo in refractory cases

leprosy (Hansen dz), paucibacillary (off-label)

[15 yo and older, pts who cannot take rifampin]

Dose: 100 mg PO qd x24mo; Info: not 1st-line agent; part of multi-drug regimen; give w/ adequate fluid to decr. esophageal irritation/ulceration; may continue tx beyond 24mo in refractory cases

renal dosing

[IR form]

renal impairment: decr. usual dose and/or frequency, amount not defined, max 200 mg/day

HD/PD: not defined

[ER form]

renal impairment: decr. usual dose and/or frequency, amount not defined

HD/PD: not defined

hepatic dosing

[not defined]