budesonide

Adult Dosing .

Dosage forms:  DR CAP: 3 mg; ER TAB: 9 mg

Crohn dz, mild-moderate

[delayed-release form, treatment]

Dose: 9 mg PO qam for up to 8wk; Info: for active dz in ileum or ascending colon; may repeat course for recurrences; may open cap, but do not crush/chew contents

[delayed-release form, remission maintenance]

Dose: 6 mg PO qam for up to 3mo; Info: for dz in ileum or ascending colon; taper dose gradually to D/C; tx duration >3mo rarely more effective; may open cap, but do not crush/chew contents

ulcerative colitis, mild-moderate active

[extended-release form]

Dose: 9 mg ER PO qam for up to 8wk; Info: do not cut/crush/chew tab

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[delayed-release form]

Child-Pugh Class B: consider decr. usual dose to 3 mg qam; Child-Pugh Class C: avoid use

[extended-release form]

mild impairment: no adjustment; moderate-severe impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  DR CAP: 3 mg

Crohn dz, mild-moderate

[treatment, 8 yo and older, >25 kg]

Dose: 9 mg PO qam for up to 8wk, then 6 mg PO qam x2wk; Info: for active dz in ileum or ascending colon; may open cap, but do not crush/chew contents

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

hepatic dosing

[see below]

Child-Pugh Class B: consider decr. usual dose to 3 mg qam; Child-Pugh Class C: avoid use