haloperidol decanoate

Black Box Warnings .

Adult Dosing .

Dosage forms:  INJ: 50 mg per mL, 100 mg per mL

Special Note

[strength clarification]

Info: 50 mg haloperidol equivalent to 70.52 mg haloperidol decanoate; all strengths expressed as haloperidol

schizophrenia

[conversion from 10 mg/day or less PO]

Dose: 50-200 mg IM qmo; Start: 10-15x oral qd dose after establishing tolerability with PO haloperidol; if initial dose >100 mg, give 100 mg IM x1 on 1st day, then remainder of dose IM in 3-7 days; may incr. by up to 50 mg/dose IM qmo; Max: 450 mg/mo; Info: consider lower start dose in elderly or debilitated patients; may give PO dose prn if symptoms worsen during conversion; gradually taper PO haloperidol; periodically reassess need for tx; taper dose gradually to D/C if long-term use; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[conversion from >11 mg/day PO]

Dose: 50-200 mg IM qmo; Start: 10-20x oral qd dose after establishing tolerability with PO haloperidol; if initial dose >100 mg, give 100 mg IM x1 on 1st day, then remainder of dose IM in 3-7 days; may incr. by up to 50 mg/dose IM qmo; Max: 450 mg/mo; Info: consider lower start dose in elderly or debilitated patients; may give PO dose prn if symptoms worsen during conversion; gradually taper PO haloperidol; periodically reassess need for tx; taper dose gradually to D/C if long-term use; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[see below]

hepatic impairment: consider lower start dose

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.