Faslodex

Adult Dosing .

Dosage forms:  INJ (pre-filled syringe): 250 mg per 5 mL

hormone receptor-positive breast CA, advanced

[500 mg IM qmo, starting wk 9]

Start: 500 mg IM x1 on days 1, 15, 29; Info: for postmenopausal pts w/ progressive dz

hormone receptor-positive HER2-negative breast CA

[advanced dz, monotherapy]

Dose: 500 mg IM qmo, starting wk 9; Start: 500 mg IM x1 on days 1, 15, 29; Info: for postmenopausal pts

[advanced or metastatic dz, combo w/ ribociclib]

Dose: 500 mg IM qmo, starting wk 9; Start: 500 mg IM x1 on days 1, 15, 29; Info: for postmenopausal pts

[advanced or metastatic dz, combo w/ palbociclib or abemaciclib]

Dose: 500 mg IM qmo, starting wk 9; Start: 500 mg IM x1 on days 1, 15, 29; Info: for progressive dz; give w/ LHRH agonist if used for pre/perimenopausal pts

renal dosing

[see below]

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

hepatic dosing

[adjust dose amount]

Child-Pugh Class B: decr. usual dose by 50%; Child-Pugh Class C: not defined

Peds Dosing .

Dosage forms:  INJ (pre-filled syringe): 250 mg per 5 mL

progressive precocious puberty (off-label)

[4 mg/kg/dose IM qmo]

Info: for female pts w/ McCune-Albright syndrome

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: not defined

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance