zoledronic acid 4 mg injection

Adult Dosing .

Dosage forms:  INJ

hypercalcemia, malignant

[4 mg IV x1]

Max: 4 mg/dose; Info: maintain adequate hydration prior to tx; may consider retreatment after >7 days; weigh risk/benefit if Cr incr. w/ initial dose

bone metastases, solid tumor-associated

[4 mg IV q3-4wk]

Max: 4 mg/dose; Info: hold dose if Cr incr, resume when Cr w/in 10% of baseline; calcium and vitamin D supplementation recommended

skeletal-related event prevention, multiple myeloma-associated

[4 mg IV q3-4wk]

Max: 4 mg/dose; Info: hold dose if Cr incr, resume when Cr w/in 10% of baseline; calcium and vitamin D supplementation recommended

renal dosing

[hypercalcemia, malignant]

CrCl >30: no adjustment; CrCl <30: not defined, caution advised

HD/PD: not defined

[all other indications]

CrCl 50-60: 3.5 mg q3-4wk; CrCl 40-49: 3.3 mg q3-4wk; CrCl 30-39: 3 mg q3-4wk; CrCl <30: avoid use

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

osteogenesis imperfecta (off-label)

[1 yo and older]

Dose: 0.05 mg/kg/dose IV q6mo; Max: 4 mg/dose; Info: maintain adequate hydration prior to tx; calcium and vitamin D supplementation recommended if inadequate dietary intake; periodically reassess need for tx; give for 1-4y

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]