probenecid

Adult Dosing .

Dosage forms:  TAB: 500 mg

gout

[500 mg PO bid]

Start: 250 mg PO bid x7 days; Max: 2 g/day; Alt: start 500 mg PO qd-bid, then titrate to serum urate <6 mg/dL in most pts

neurosyphilis, penicillin boosting

[500 mg PO qid x10-14 days]

Info: not 1st-line agent; give w/ penicillin G procaine

mild-moderate PID, cefoxitin boosting

[1 g PO x1]

Info: give w/ cefoxitin, doxycycline, and metronidazole; 1st-line agent

nephropathy prevention, cidofovir-assoc. (off-label)

[1 g PO x1 at 2h and 8h after cidofovir infustion for 2 total doses]

Start: 2 g PO x1 3h before cidofovir infusion; Info: to prevent nephropathy; give w/ saline hydration

renal dosing

[gout]

CrCl <30: avoid use

HD/PD: avoid use

[boosting]

renal impairment: avoid use

HD/PD: avoid use

[nephropathy prevention]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  TAB: 500 mg

neurosyphilis, penicillin boosting (off-label)

[adolescents]

Dose: 500 mg PO qid x10-14 days; Info: not 1st-line agent; give w/ penicillin G procaine

mild-moderate PID, cefoxitin boosting (off-label)

[preadolescents >45 kg and adolescents]

Dose: 1 g PO x1; Info: give w/ cefoxitin, doxycycline, and metronidazole; 1st-line agent

nephropathy prevention, cidofovir-assoc. (off-label)

[13 yo and older]

Dose: 1 g PO x1 at 2h and 8h after cidofovir infustion for 2 total doses; Start: 2 g PO x1 3h before cidofovir infusion; Info: to prevent nephropathy; give w/ saline hydration

renal dosing

[nephropathy prevention]

renal impairment: not defined

HD/PD: not defined

[all other indications]

renal impairment: avoid use

HD/PD: avoid use

hepatic dosing

[not defined]