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thioridazine
generic
Black Box Warnings .
Proarrhythmic Effects
dose-related prolongation of QTc interval may cause torsades de pointes-type arrhythmias and sudden death; restrict use to schizophrenia resistant to standard antipsychotic drugs either due to insufficient efficacy or inability to reach effective dose due to intolerable adverse effects
Dementia-Related Psychosis
not approved for dementia-related psychosis; incr. mortality risk in elderly dementia pts on conventional or atypical antipsychotics; most deaths due to cardiovascular or infectious events
Adult Dosing .
Dosage forms: TAB: 10 mg, 25 mg, 50 mg, 100 mg; SOL: 100 mg per mL
schizophrenia, refractory
- [200-800 mg/day PO divided bid-qid]
- Start: 50-100 mg PO tid; Max: 800 mg/day; Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.