flumazenil

Adult Dosing .

Dosage forms:  INJ

benzodiazepine sedation reversal

[0.2 mg IV qmin x1-5 doses]

Max: 1 mg total dose; 3 mg/h; Info: admin. IV push over 15sec; may repeat q20min for resedation

benzodiazepine overdose

[0.2-0.5 mg IV qmin]

Start: 0.2 mg IV x1, wait 30sec, then 0.3 mg IV x1 prn, wait 30sec then 0.5 mg IV qmin prn up to x6; Max: 5 mg total; Info: admin. IV push over 30sec; consider alternative if no response after 3-5min; may repeat 0.5 mg IV qmin x2 q20min up to 3 mg/h for resedation after initial response

renal dosing

[see below]

renal impairment: no adjustment

HD: no adjustment; no supplement after dialysis; PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  INJ

benzodiazepine sedation reversal

[1 yo and older]

Dose: 0.01 mg/kg/dose IV qmin x1-5 doses; Max: 0.2 mg/dose; 0.05 mg/kg up to 1 mg total dose; Info: admin. IV push over 15sec

benzodiazepine overdose (off-label)

[1 yo and older]

Dose: 0.01 mg/kg/dose IV qmin prn; Max: 0.2 mg/dose; 0.05 mg/kg up to 1 mg total dose; Alt: 0.01 mg/kg/dose IV x1, then 0.005-0.01 mg/kg/h IV; Info: admin. IV push over 30sec

renal dosing

[see below]

renal impairment: no adjustment

HD: no adjustment; no supplement after dialysis; PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised