Select a medication above to begin.
meclofenamate
generic
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, including MI and stroke; risk may occur early in tx and may incr. with duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events including bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and without warning symptoms; elderly patients and patients with history of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: CAP: 50 mg, 100 mg
pain, mild-moderate
- [50-100 mg PO q4-6h]
- Max: 400 mg/day; Info: use lowest effective dose, shortest effective tx duration; give with food if GI upset occurs
dysmenorrhea, primary
- [100 mg PO tid for up to 6 days]
- Start: at menses onset; Info: use lowest effective dose, shortest effective tx duration; give with food if GI upset occurs
heavy menstrual bleeding, idiopathic
- [100 mg PO tid for up to 6 days]
- Start: at menses onset; Info: use lowest effective dose, shortest effective tx duration; give with food if GI upset occurs
osteoarthritis
- [200-400 mg/day PO divided tid-qid]
- Start: 200 mg/day PO divided tid-qid; Max: 400 mg/day; Info: use lowest effective dose, shortest effective tx duration; give with food if GI upset occurs
rheumatoid arthritis
- [200-400 mg/day PO divided tid-qid]
- Start: 200 mg/day PO divided tid-qid; Max: 400 mg/day; Info: use lowest effective dose, shortest effective tx duration; give with food if GI upset occurs
ankylosing spondylitis
- [200-400 mg/day PO divided tid-qid]
- Start: 200 mg/day PO divided tid-qid; Max: 400 mg/day; Info: use lowest effective dose, shortest effective tx duration; give with food if GI upset occurs
gout, acute
- [100 mg PO tid-qid]
- Start: 200 mg PO x1, then 100 mg PO q4h x1 day; Max: 400 mg/day; Info: use lowest effective dose, shortest effective tx duration; give with food if GI upset occurs
renal dosing
- [see below]
- CrCl >60: no adjustment; CrCl 30-60: not defined, caution advised; CrCl <30: avoid use
- HD/PD: avoid use
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: CAP: 50 mg, 100 mg
juvenile idiopathic arthritis
- [14 yo and older]
- Dose: 200-400 mg/day PO divided tid-qid; Start: 200 mg/day PO divided tid-qid; Max: 400 mg/day; Info: use lowest effective dose, shortest effective tx duration; give with food if GI upset occurs
dysmenorrhea, primary
- [14 yo and older]
- Dose: 100 mg PO tid for up to 6 days; Start: at menses onset; Info: use lowest effective dose, shortest effective tx duration; give with food if GI upset occurs
heavy menstrual bleeding, idiopathic
- [14 yo and older]
- Dose: 100 mg PO tid for up to 6 days; Start: at menses onset; Info: use lowest effective dose, shortest effective tx duration; give with food if GI upset occurs
renal dosing
- [see below]
- CrCl >60: no adjustment; CrCl 30-60: not defined, caution advised; CrCl <30: avoid use
- HD/PD: avoid use
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised