palonosetron

Adult Dosing .

Dosage forms:  INJ

nausea/vomiting prevention, chemo-related

[0.25 mg IV x1 on day 1]

Start: 30min before chemo; Info: for pts receiving moderately- or highly-emetogenic parenteral chemo; part of multi-drug regimen; search 'CINV' for epocrates Chemo-Induced Nausea & Vomiting in Adults decision tool

nausea/vomiting prevention, postop

[0.075 mg IV x1]

Start: immed. before anesthesia induction

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  INJ

nausea/vomiting prevention, chemo-related

[1 mo-16 yo]

Dose: 20 mcg/kg/dose IV x1; Start: 30min before chemo; Max: 1.5 mg/dose; Info: for pts receiving moderately- or highly-emetogenic chemo

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[no adjustment]