Rydapt

Adult Dosing .

Dosage forms:  CAP: 25 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, and dosing incl. toxicity-related dose adjustments

FLT3-positive AML, newly diagnosed

[induction tx]

Dose: 50 mg PO bid on days 8-21 of each cycle; Info: part of multi-drug chemo regimen; give w/ food

[consolidation tx]

Dose: 50 mg PO bid on days 8-21 of each cycle; Info: use w/ cytarabine; give w/ food

systemic mastocytosis

[100 mg PO bid]

Info: for pts w/ aggressive systemic mastocytosis, systemic mastocytosis w/ assoc. hematological neoplasm, or mast cell leukemia; give w/ food

renal dosing

[see below]

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

hepatic dosing

[see below]

bilirubin 1-3x ULN or AST >ULN: no adjustment; bilirubin >3x ULN: not defined

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.