varenicline

Adult Dosing .

Dosage forms:  TAB: 0.5 mg, 1 mg; TAB (1-mo starter pack): 0.5 mg x11 and 1 mg x42

Dosage Form Details

[formulation clarification]

Info: brand withdrawn in US September 16, 2021 due to contamination w/ potential carcinogen N-nitroso-varenicline; generic forms may contain N-nitroso-varenicline above FDA acceptable daily intake limits

smoking cessation

[1 mg PO bid x11wk]

Start: 0.5 mg PO qd x3 days, then 0.5 mg PO bid x4 days; Max: 2 mg/day; Info: give w/ food; start drug 1wk before quit date if quit date planned; stop smoking 8-35 days after starting drug if quit date unplanned; initial tx = 12wk (1 starting pack + 2 continuing packs); may cont. additional 12wk if initial tx successful

renal dosing

[adjust dose amount, frequency]

CrCl <30: start 0.5 mg qd, max 0.5 mg bid

HD: max 0.5 mg qd, on dialysis days admin. after dialysis; supplement not defined; PD: not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  TAB: 0.5 mg, 1 mg; TAB (1-mo starter pack): 0.5 mg x11 and 1 mg x42

Dosage Form Details

[formulation clarification]

Info: brand withdrawn in US September 16, 2021 due to contamination w/ potential carcinogen N-nitroso-varenicline; generic forms may contain N-nitroso-varenicline above FDA acceptable daily intake limits

smoking cessation (off-label)

[17 yo and older]

Dose: 1 mg PO bid x11wk; Start: 0.5 mg PO qd x3 days, then 0.5 mg PO bid x4 days; Max: 2 mg/day; Info: give w/ food; start drug 1wk before quit date if quit date planned; stop smoking 8-35 days after starting drug if quit date unplanned; initial tx = 12wk (1 starting pack + 2 continuing packs); may cont. additional 12wk if initial tx successful

renal dosing

[adjust dose amount, frequency]

CrCl <30: start 0.5 mg qd, max 0.5 mg bid

HD: max 0.5 mg qd, on dialysis days admin. after dialysis; supplement not defined; PD: not defined

hepatic dosing

[no adjustment]