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ambrisentan
generic
Black Box Warnings .
Embryo-Fetal Toxicity
contraindicated in pregnancy due to risk of fetal harm; exclude pregnancy prior to tx initiation; avoid pregnancy by using effective methods of contraception prior to tx start, during tx, and x1mo after D/C; D/C ASAP if pregnancy detected
Adult Dosing .
Dosage forms: TAB: 5 mg, 10 mg
pulmonary arterial HTN
- [5-10 mg PO qd]
- Start: 5 mg PO qd, may incr. to 10 mg PO qd after 4wk if tolerated; Max: 10 mg/day; Info: do not cut/crush/chew tab
renal dosing
- [see below]
- mild-moderate impairment: no adjustment; severe impairment: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- mild impairment: not defined, caution advised; moderate-severe impairment: avoid use
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.