Isentress

Adult Dosing .

Dosage forms:  TAB: 400 mg

HIV infection

[400 mg PO bid]

HIV post-exposure prophylaxis, occupational (off-label)

[400 mg PO bid]

Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Occupational table

renal dosing

[no adjustment]

renal impairment: no adjustment

HD: no adjustment, on dialysis days administer after dialysis; consider supplement if next maintenance dose not due right after dialysis; PD: no adjustment; supplement not defined

hepatic dosing

[see below]

mild-moderate impairment: no adjustment; severe impairment: not defined

Peds Dosing .

Dosage forms:  TAB: 400 mg; CHEWABLE: 25 mg, 100 mg; POWDER: 100 mg per packet

Special Note

[strength clarification]

Info: recommended reconstitution of powder yields 10 mg per mL oral suspension

[equivalency or interchangeability info]

Info: raltegravir chewable tabs and oral suspension not bioequivalent or interchangeable with tabs; reassess dose if switching between products

HIV infection

[0-1 wk old, 2-2.9 kg]

Dose: 4 mg suspension PO qd; Start: 24-48h after birth if gestational parent has taken raltegravir 2-24h before delivery, otherwise start within 12h after birth; Info: for full-term neonates

[0-1 wk old, 3-3.9 kg]

Dose: 5 mg suspension PO qd; Start: 24-48h after birth if gestational parent has taken raltegravir 2-24h before delivery, otherwise start within 12h after birth; Info: for full-term neonates

[0-1 wk old, 4-4.9 kg]

Dose: 7 mg suspension PO qd; Start: 24-48h after birth if gestational parent has taken raltegravir 2-24h before delivery, otherwise start within 12h after birth; Info: for full-term neonates

[1-4 wk old, 2-2.9 kg]

Dose: 8 mg suspension PO bid; Start: 24-48h after birth if gestational parent has taken raltegravir 2-24h before delivery, otherwise start within 12h after birth; Info: for full-term neonates

[1-4 wk old, 3-3.9 kg]

Dose: 10 mg suspension PO bid; Start: 24-48h after birth if gestational parent has taken raltegravir 2-24h before delivery, otherwise start within 12h after birth; Info: for full-term neonates

[1-4 wk old, 4-4.9 kg]

Dose: 15 mg suspension PO bid; Start: 24-48h after birth if gestational parent has taken raltegravir 2-24h before delivery, otherwise start within 12h after birth; Info: for full-term neonates

[4 wk old and older, 3-3.9 kg]

Dose: 25 mg suspension PO bid; Alt: 25 mg chewable tab PO bid

[4 wk old and older, 4-5.9 kg]

Dose: 30 mg suspension PO bid; Alt: 25 mg chewable tab PO bid

[4 wk old and older, 6-7.9 kg]

Dose: 40 mg suspension PO bid; Alt: 50 mg chewable tab PO bid

[4 wk old and older, 8-9.9 kg]

Dose: 60 mg suspension PO bid; Alt: 50 mg chewable tab PO bid

[4 wk old and older, 10-13.9 kg]

Dose: 80 mg suspension PO bid; Alt: 75 mg chewable tab PO bid

[4 wk old and older, 14-19.9 kg]

Dose: 100 mg suspension PO bid; Alt: 100 mg chewable tab PO bid

[4 wk old and older, 20-24.9 kg]

Dose: 150 mg chewable tab PO bid

[4 wk old and older, 25-27.9 kg]

Dose: 400 mg tab PO bid; Alt: 150 mg chewable tab PO bid

[4 wk old and older, 28-39.9 kg]

Dose: 400 mg tab PO bid; Alt: 200 mg chewable tab PO bid

[4 wk old and older, >40 kg]

Dose: 400 mg tab PO bid; Alt: 300 mg chewable tab PO bid

HIV infection prevention, high-risk neonates (off-label)

[>37 wk gestation, <1 wk old, 2-4 kg]

Dose: 1.5 mg/kg/dose PO qd x2-6wk; Start: within 6h after birth; Info: give with lamivudine and zidovudine; if <6wk multidrug regimen, continue zidovudine alone to complete 6wk total duration; refer to DHHS guidelines

[>37 wk gestation, 1-4 wk old, 2-4 kg]

Dose: 3 mg/kg/dose PO bid x2-6wk; Start: within 6h after birth; Info: give with lamivudine and zidovudine; if <6wk multidrug regimen, continue zidovudine alone to complete 6wk total duration; refer to DHHS guidelines

[>37 wk gestation, 4-6 wk old, 3-7 kg]

Dose: 6 mg/kg/dose PO bid x2-6wk; Start: within 6h after birth; Info: give with lamivudine and zidovudine; if <6wk multidrug regimen, continue zidovudine alone to complete 6wk total duration; refer to DHHS guidelines

HIV post-exposure prophylaxis, nonoccupational (off-label)

[2-12 yo, 11-13.9 kg]

Dose: 75 mg chewable tab PO bid; Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table

[2-12 yo, 14-19.9 kg]

Dose: 100 mg chewable tab PO bid; Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table

[2-12 yo, 20-27.9 kg]

Dose: 150 mg chewable tab PO bid; Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table

[2-12 yo, 28-39.9 kg]

Dose: 200 mg chewable tab PO bid; Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table

[2-12 yo, >40 kg]

Dose: 300 mg chewable tab PO bid; Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table

[6-12 yo, >25 kg]

Dose: 400 mg tab PO bid; Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table

renal dosing

[no adjustment]

renal impairment: no adjustment

HD: no adjustment, on dialysis days administer after dialysis; consider supplement if next maintenance dose not due right after dialysis; PD: no adjustment; supplement not defined

hepatic dosing

[see below]

mild-moderate impairment: no adjustment; severe impairment: not defined