Select a medication above to begin.
lomustine
generic
Black Box Warnings .
Delayed Myelosuppression
severe, including fatal cases have occurred; myelosuppression is delayed, dose-related, and cumulative; thrombocytopenia is generally more severe than leukopenia; monitor CBC with diff for at least 6wk after dose; do not dose more frequently than q6wk
Risk of Overdosage
Prescribe, dispense, and administer only enough caps for 1 dose; fatal toxicity occurs with overdose; physicians and pharmacists should emphasize to patients that only 1 dose is taken q6wk
Adult Dosing .
Dosage forms: CAP: 10 mg, 40 mg, 100 mg
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, and dosing including toxicity-related dose adjustments
brain tumors, primary and metastatic
- [130 mg/m^2/dose PO x1 on day 1 of 42-day cycle]
- Info: round dose to nearest 10 mg; give 100 mg/m^2/dose PO x1 on day 1 of 42-day cycle if baseline compromised bone marrow function
Hodgkin lymphoma, relapsed or refractory
- [130 mg/m^2/dose PO x1 on day 1 of 42-day cycle]
- Info: round dose to nearest 10 mg; give 100 mg/m^2/dose PO x1 on day 1 of 42-day cycle if baseline compromised bone marrow function; part of multi-drug chemo regimen
renal dosing
- [adjust dose amount]
- CrCl 10-50: decr. usual dose by 25-50%; CrCl <10: decr. usual dose by 50-75%
- HD: decr. usual dose by 50-75%; no supplement after dialysis; PD: decr. usual dose by 50-75%; supplement not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: CAP: 10 mg, 40 mg, 100 mg
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, and dosing including toxicity-related dose adjustments
brain tumors, primary and metastatic
- [130 mg/m^2/dose PO x1 on day 1 of 42-day cycle]
- Info: round dose to nearest 10 mg; give 100 mg/m^2/dose PO x1 on day 1 of 42-day cycle if baseline compromised bone marrow function
Hodgkin lymphoma, relapsed or refractory
- [130 mg/m^2/dose PO x1 on day 1 of 42-day cycle]
- Info: round dose to nearest 10 mg; give 100 mg/m^2/dose PO x1 on day 1 of 42-day cycle if baseline compromised bone marrow function; part of multi-drug chemo regimen
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: consider adult renal dosing for guidance
hepatic dosing
- [not defined]