fosaprepitant

Adult Dosing .

Dosage forms:  INJ

Special Note

[dosing clarification]

Info: for PO aprepitant dosing see aprepitant or Emend; for IV aprepitant dosing see Aponvie or Cinvanti

nausea/vomiting prevention, chemo-related

[150 mg IV x1 on day 1, completed 30min before chemo start]

Info: for pts receiving moderately- or highly-emetogenic parenteral chemo; part of multi-drug regimen; search 'CINV' for epocrates Chemo-Induced Nausea & Vomiting in Adults decision tool

renal dosing

[see below]

renal impairment: no adjustment

HD: no adjustment; no supplement; PD: not defined

hepatic dosing

[see below]

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

Peds Dosing .

Dosage forms:  INJ

Special Note

[formulation clarification]

Info: products may contain different edetate disodium (EDTA) amounts; reduced EDTA-containing forms = 5.4 mg, higher EDTA-containing forms = 18.8 mg; only reduced EDTA-containing forms have been found safe for use in pediatric pts

[dosing clarification]

Info: for PO aprepitant dosing see aprepitant or Emend

nausea/vomiting prevention, chemo-related

[1-day regimen, 6 mo-1 yo, >6 kg]

Dose: 5 mg/kg/dose IV x1 on day 1, completed 30min before chemo start; Max: 150 mg/dose; Info: for pts receiving moderately- or highly-emetogenic chemo; give w/ 5-HT3 antagonist and w/ or w/o corticosteroid

[1-day regimen, 2-11 yo]

Dose: 4 mg/kg/dose IV x1 on day 1, completed 30min before chemo start; Max: 150 mg/dose; Info: for pts receiving moderately- or highly-emetogenic chemo; give w/ 5-HT3 antagonist and w/ or w/o corticosteroid

[1-day regimen, 12-17 yo]

Dose: 150 mg IV x1 on day 1, completed 30min before chemo start; Info: for pts receiving moderately- or highly-emetogenic chemo; give w/ 5-HT3 antagonist and w/ or w/o corticosteroid

[3-day regimen, 6 mo-11 yo, >6 kg]

Dose: 3 mg/kg/dose IV x1 on day 1, then 2 mg/kg/dose IV qd on days 2-3; Max: 115 mg on day 1, 80 mg/day on days 2-3; Alt: 3 mg/kg/dose IV x1 on day 1, then oral aprepitant 2 mg/kg/dose PO qam on days 2-3; Info: for pts receiving moderately- or highly-emetogenic chemo; give w/ 5-HT3 antagonist and w/ or w/o corticosteroid; complete IV infusion 30min before chemo start; give PO aprepitant 1h before chemo

[3-day regimen, 12-17 yo]

Dose: 115 mg IV x1 on day 1, then 80 mg IV qd on days 2-3; Alt: 115 mg IV x1 on day 1, then oral aprepitant 80 mg PO qam on days 2-3; Info: for pts receiving moderately- or highly-emetogenic chemo; give w/ 5-HT3 antagonist and w/ or w/o corticosteroid; complete IV infusion 30min before chemo start; give PO aprepitant 1h before chemo

renal dosing

[see below]

renal impairment: no adjustment

HD: no adjustment; no supplement; PD: not defined

hepatic dosing

[see below]

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined