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alvimopan
generic
Black Box Warnings .
Appropriate Use
alvimopan available only through restricted program for short-term use (15 doses) in hospitalized patients; hospitals must be registered and meet all requirements for Alvimopan REMS program
Myocardial Infarction Risk
incr. MI incidence during 12mo study with alvimopan compared to placebo, although causal relationship not established; no incr. MI risk observed in short-term study
Adult Dosing .
Dosage forms: CAP: 12 mg
Restricted Distribution in US
- [1-800-278-0340 or www.alvimopanREMS.com for more info]
ileus, postop
- [12 mg PO bid for up to 7 days]
- Start: 12 mg PO x1 30min-5h before surgery; Max: 15 doses; Info: start bid dosing the day after surgery
renal dosing
- [see below]
- renal impairment: no adjustment; ESRD: avoid use; Info: metabolite accumulation possible in severe impairment with multiple doses
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class C: avoid use
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.