HepaGam B

Adult Dosing .

Dosage forms:  INJ

hepatitis B infection prophylaxis, post-exposure

[blood exposure]

Dose: 0.06 mL/kg/dose IM x1; Start: w/in 24h of exposure if possible; Info: may give up to 7 days after exposure; give w/ HBV vaccine series if unvaccinated; may give w/ HBV vaccine booster dose if previously vaccinated; repeat dose in 1mo for patients who refuse HBV vaccine or are nonresponders to vaccine

[sexual exposure]

Dose: 0.06 mL/kg/dose IM x1; Start: w/in 14 days of exposure; Info: give w/ HBV vaccine series

[household exposure]

Dose: 0.06 mL/kg/dose IM x1; Start: w/in 14 days of exposure; Info: for patients w/ identifiable blood exposure to individuals w/ acute HBV infection; give w/ HBV vaccine series

hepatitis B infection prevention, post-transplant

[20,000 units IV qmo]

Start: 20,000 units IV x1 in anhepatic phase, then 20,000 units IV qd x7 days, then 7 days later, 20,000 units IV q2wk x10wk; Info: for HBsAg-positive liver transplant patients; if anti-HBs antibody levels <500 units/L w/in 7 days post-transplant, give 10,000 units IV q6h until target anti-HBs antibody levels reached

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

hepatitis B infection prophylaxis, post-exposure

[blood exposure]

Dose: 0.06 mL/kg/dose IM x1; Start: w/in 24h of exposure if possible; Info: may give up to 7 days after exposure; give w/ HBV vaccine series if unvaccinated; may give w/ HBV vaccine booster dose if previously vaccinated; repeat dose in 1mo for patients who refuse HBV vaccine or are nonresponders to vaccine

[perinatal exposure]

Dose: 0.5 mL IM x1; Start: w/in 12h or birth; Info: for newborns w/ HbsAg-positive gestational parent, or HBsAg status unknown gestational parent if wt <2 kg; may give up to 7 days after birth if HBsAg-unknown gestational parent tests positive; give w/ HBV vaccine series

[household exposure, patients <12 mo]

Dose: 0.5 mL IM x1; Info: for patients whose primary caregiver has acute HBV infection; give w/ HBV vaccine series

[household exposure, patients 12 mo and older]

Dose: 0.06 mL/kg/dose IM x1; Start: w/in 14 days of exposure; Info: for patients w/ identifiable blood exposure to individuals w/ acute HBV infection; give w/ HBV vaccine series

[sexual exposure]

Dose: 0.06 mL/kg/dose IM x1; Start: w/in 14 days of exposure; Info: give w/ HBV vaccine series

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]