Select a medication above to begin.
NovoSeven RT
coagulation factor VIIa (recombinant)
Black Box Warnings .
Thrombosis
serious arterial and venous thrombotic/thromboembolic events, including fatal, have been reported; counsel patients on thrombosis risk and signs/symptoms; monitor patients for coagulation system activation and thrombosis signs/symptoms
Adult Dosing .
Dosage forms: INJ
congenital hemophilia A or B with inhibitors
- [bleeding episode]
- Dose: 90 mcg/kg/dose IV q2h until hemostasis; Info: continue q3-6h after hemostasis if severe bleeding; individualize dose, frequency
- [bleeding prophylaxis, minor surgery]
- Dose: 90 mcg/kg/dose IV x1 immediately before surgery, then q2h during surgery and x48h after surgery, then q2-6h until healed; Info: individualize dose, frequency
- [bleeding prophylaxis, major surgery]
- Dose: 90 mcg/kg/dose IV x1 immediately before surgery, then q2h during surgery and x5 days after surgery, then q4h until healed; Alt: 90 mcg/kg/dose IV x1 immediately before surgery, then q2h during surgery, then 50 mcg/kg/hr until healed; Info: individualize dose, frequency
acquired hemophilia
- [bleeding episode]
- Dose: 70-90 mcg/kg/dose IV q2-3h until hemostasis; Info: individualize dose, frequency
- [bleeding prophylaxis, surgery]
- Dose: 70-90 mcg/kg/dose IV x1 immediately before surgery, then q2-3h during and after surgery until hemostasis; Info: individualize dose, frequency
congenital factor VII deficiency
- [bleeding episode]
- Dose: 10-30 mcg/kg/dose IV q4-6h until hemostasis; Info: monitor FVII:C, PT before and after tx; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors
- [bleeding prophylaxis, surgery]
- Dose: 10-30 mcg/kg/dose IV x1 immediately before surgery, then q4-6h during and after surgery until hemostasis; Info: monitor FVII:C, PT before and after tx; dose, duration varies by severity of deficiency and presence of inhibitors
Glanzmann thrombasthenia
- [bleeding episode]
- Dose: 90 mcg/kg/dose IV q2-6h until hemostasis; Info: individualize dose, frequency
- [bleeding prophylaxis, surgery]
- Dose: 90 mcg/kg/dose IV x1 immediately before surgery, then q2h during surgery, then q2-6h after surgery to prevent postop bleeding; Info: individualize dose, frequency
warfarin overanticoagulation (off-label)
- [15-90 mcg/kg/dose IV x1]
- Info: for INR reversal in life-threatening hemorrhage; refer to ACCP guidelines or institutional protocols
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ
congenital hemophilia A or B with inhibitors
- [bleeding episode]
- Dose: 90 mcg/kg/dose IV q2h until hemostasis; Info: continue q3-6h after hemostasis if severe bleeding; individualize dose, frequency
- [bleeding prophylaxis, minor surgery]
- Dose: 90 mcg/kg/dose IV x1 immediately before surgery, then q2h during surgery and x48h after surgery, then q2-6h until healed; Info: individualize dose, frequency
- [bleeding prophylaxis, major surgery]
- Dose: 90 mcg/kg/dose IV x1 immediately before surgery, then q2h during surgery and x5 days after surgery, then q4h until healed; Alt: 90 mcg/kg/dose IV x1 immediately before surgery, then q2h during surgery, then 50 mcg/kg/hr until healed; Info: individualize dose, frequency
congenital factor VII deficiency
- [bleeding episode]
- Dose: 10-30 mcg/kg/dose IV q4-6h until hemostasis; Info: monitor FVII:C, PT before and after tx; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors
- [bleeding prophylaxis, surgery]
- Dose: 10-30 mcg/kg/dose IV x1 immediately before surgery, then q4-6h during and after surgery until hemostasis; Info: monitor FVII:C, PT before and after tx; dose, duration varies by severity of deficiency and presence of inhibitors
Glanzmann thrombasthenia
- [bleeding episode]
- Dose: 90 mcg/kg/dose IV q2-6h until hemostasis; Info: individualize dose, frequency
- [bleeding prophylaxis, surgery]
- Dose: 90 mcg/kg/dose IV x1 immediately before surgery, then q2h during surgery, then q2-6h after surgery to prevent postop bleeding; Info: individualize dose, frequency
acquired hemophilia (off-label)
- [bleeding episode]
- Dose: 70-90 mcg/kg/dose IV q2-3h until hemostasis; Info: individualize dose, frequency
- [bleeding prophylaxis, surgery]
- Dose: 70-90 mcg/kg/dose IV x1 immediately before surgery, then q2-3h during and after surgery until hemostasis; Info: individualize dose, frequency
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]