Braftovi

Adult Dosing .

Dosage forms:  CAP: 75 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

BRAF V600E- or V600K-positive melanoma, unresectable or metastatic

[450 mg PO qd]

Info: use w/ binimetinib; decr. dose to max 300 mg PO qd if binimetinib withheld

BRAF V600E-positive colorectal CA, metastatic

[first-line tx]

Dose: 300 mg PO qd; Info: part of multi-drug chemo regimen

[previously treated dz]

Dose: 300 mg PO qd; Info: use w/ cetuximab

BRAF V600E-positive non-small cell lung CA, metastatic

[450 mg PO qd]

Info: use w/ binimetinib; decr. dose to max 300 mg PO qd if binimetinib withheld

renal dosing

[see below]

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class A: no adjustment; Child-Pugh Class B or C: not defined

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.