Select a medication above to begin.
Cozaar
losartan
Black Box Warnings .
Fetal Toxicity
fetal/neonatal morbidity/mortality may occur when drugs that act directly on the renin-angiotensin system are used in pregnancy; D/C drug ASAP once pregnancy detected
Adult Dosing .
Dosage forms: TAB: 25 mg, 50 mg, 100 mg
HTN
- [50-100 mg/day PO divided qd-bid]
- Start: 50 mg PO qd; Max: 100 mg/day; Info: start 25 mg PO qd if on diuretic
nephropathy, diabetic
- [100 mg PO qd]
- Start: 50 mg PO qd; Max: 100 mg/day; Info: for pts w/ type 2 DM and HTN
stroke prevention
- [50-100 mg PO qd]
- Start: 50 mg PO qd; Max: 100 mg/day; Info: for pts w/ HTN and LVH; possibly ineffective in Black pts; may give w/ HCTZ
heart failure w/ reduced ejection fraction (off-label)
- [50-150 mg PO qd]
- Start: 25-50 mg PO qd; Max: 150 mg/day
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [adjust dose amount]
- hepatic impairment: start 25 mg qd
Peds Dosing .
- Dosage forms: TAB: 25 mg, 50 mg, 100 mg
HTN
- [6 yo and older]
- Dose: 0.7-1.4 mg/kg/dose PO qd; Start: 0.7 mg/kg/dose PO qd up to 50 mg/day; Max: 1.4 mg/kg/day up to 100 mg/day; Info: see pkg insert for suspension preparation
aortic dilation, Marfan syndrome-assoc. (off-label)
- [1 yo and older]
- Dose: 1-1.4 mg/kg/dose PO qd; Start: 0.4 mg/kg/dose PO qd; Max: 100 mg/day; Info: see pkg insert for suspension preparation
renal dosing
- [see below]
- CrCl >30: no adjustment; CrCl <30: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
- hepatic impairment: consider adult hepatic dosing for guidance