Select a medication above to begin.
penicillamine
generic
Black Box Warnings .
Appropriate Use
physicians should be familiar w/ toxicity, special dosage considerations, and therapeutic benefits; never use casually; pt must remain under constant close physician supervision; warn pt to promptly report toxicity sx
Adult Dosing .
Dosage forms: CAP: 250 mg; TAB: 250 mg
cystinuria
- [500 mg PO qid]
- Start: 250 mg PO qd, incr. gradually; Max: 4000 mg/day; Info: for pts w/o adequate response or adherence to conventional tx; divide doses >500 mg/day; if divided doses unequal, give larger dose qhs; adjust dose based on urinary cystine excretion; decr. dose to 250 mg/day if surgery until wound healing complete; give 1h before or 2h after meals; give w/ pyridoxine 25 mg/day
rheumatoid arthritis, severe
- [250-500 mg PO bid-tid]
- Start: 125-250 mg PO qd, incr. dose 125-250 mg/day q1-3mo; Info: for pts w/o adequate response to conventional tx; divide doses >500 mg/day; D/C if inadequate response w/ 1000-1500 mg/day x3-4mo; decr. dose to 250 mg/day if surgery until wound healing complete; give 1h before or 2h after meals; give w/ pyridoxine 25 mg/day
Wilson dz
- [750-1500 mg/day PO divided tid-qid]
- Start: 250 mg PO qd, incr. gradually; Info: divide doses >500 mg/day; adjust dose based on 24h urinary copper excretion and free serum copper; decr. dose to 250 mg/day if surgery until wound healing complete; in pregnant pts, max 750 mg cap/day or 1000 mg tab/day; give 1h before or 2h after meals; give w/ pyridoxine 25 mg/day
renal dosing
- [rheumatoid arthritis]
- renal impairment: contraindicated
- HD/PD: contraindicated
- [all other indications]
- CrCl <60: avoid use
- HD: decr. usual dose by at least 50%, on dialysis days admin. after dialysis; supplement not defined; PD: avoid use
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: CAP: 250 mg; TAB: 250 mg
cystinuria
- [30 mg/kg/day PO divided qid]
- Max: 4000 mg/day; Info: for pts w/o adequate response or adherence to conventional tx; divide doses >500 mg/day; if divided doses unequal, give larger dose qhs; adjust dose based on urinary cystine excretion; decr. dose if surgery until wound healing complete; give 1h before or 2h after meals; give w/ pyridoxine 25 mg/day
Wilson dz (off-label)
- [20 mg/kg/day PO divided bid-qid]
- Max: 1000 mg/day; Info: divide doses >500 mg/day; adjust dose based on 24h urinary copper excretion and free serum copper; decr. dose if surgery until wound healing complete; in pregnant pts, max 750 mg cap/day or 1000 mg tab/day; give 1h before or 2h after meals; give w/ pyridoxine 25 mg/day
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: consider adult renal dosing for guidance
hepatic dosing
- [not defined]