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telmisartan/ amlodipine
generic
Black Box Warnings .
Fetal Toxicity
fetal/neonatal morbidity/mortality may occur when drugs that act directly on the renin-angiotensin system are used in pregnancy; D/C drug ASAP once pregnancy detected
Adult Dosing .
Dosage forms: TAB: 40 mg/5 mg, 40 mg/10 mg, 80 mg/5 mg, 80 mg/10 mg
HTN
- [initial therapy]
- Dose: 1 tab PO qd; Start: 40 mg/5 mg or 80 mg/5 mg PO qd, may incr. dose after 2wk; Max: 80 mg/10 mg/day; Info: for use as initial tx if BP control unlikely on single agent; not recommended as initial tx in pts 75 yo and older
- [replacement/add-on therapy]
- Dose: 1 tab PO qd; Start: same doses of both components if replacement tx or higher dose if BP control not achieved on prior tx; start combo at 40 mg/5 mg/day if not tolerating prior 10 mg/day amlodipine dose; Max: 80 mg/10 mg/day; Info: may incr. dose after 2wk
renal dosing
- [see below]
- renal impairment: no adjustment; Info: titrate slowly if severe impairment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- hepatic impairment: avoid use as initial tx, lower amlodipine dose not possible w/ fixed-dose combo
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.