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Vibativ
telavancin
Black Box Warnings .
Increased Mortality if Renal Impairment in Bacterial Pneumonia
use only if benefit outweighs risk; incr. mortality compared to vancomycin in hospital-acquired or ventilator-associated bacterial pneumonia patients with pre-existing CrCl <50
Nephrotoxicity
monitor renal function; new onset or worsening renal impairment has occurred
Fetal Risk
may cause fetal harm; adverse developmental outcomes observed in animal species; verify pregnancy status prior to tx start; advise pregnant patients of potential risk of fetal harm; advise patients of childbearing potential to use effective contraception during tx and x2 days after D/C
Adult Dosing .
Dosage forms: INJ
skin/skin structure infections, complicated bacterial
- [10 mg/kg/dose IV q24h x7-14 days]
- Info: duration varies by infection site/severity
pneumonia, hospital-acquired or ventilator-associated
- [10 mg/kg/dose IV q24h x7 days]
- Info: may extend duration based on clinical response; refer to IDSA guidelines
renal dosing
- [skin/skin structure infections]
- CrCl 30-50: 7.5 mg/kg/dose q24h; CrCl 10-29: 10 mg/kg/dose q48h; CrCl <10: not defined; Info: risk of IV vehicle accumulation; decr. efficacy in patients with CrCl <50
- HD: consider 10 mg/kg/dose q48h or 10 mg/kg/dose 3x/wk after dialysis; no supplement; PD: not defined; Info: risk of IV vehicle accumulation; decr. efficacy in patients with CrCl <50
- [pneumonia]
- CrCl 30-50: 7.5 mg/kg/dose q24h; CrCl 10-29: 10 mg/kg/dose q48h; CrCl <10: not defined; Info: risk of IV vehicle accumulation; weigh risk/benefit if CrCl <50
- HD: consider 10 mg/kg/dose q48h or 10 mg/kg/dose 3x/wk after dialysis; no supplement; PD: not defined; Info: risk of IV vehicle accumulation; weigh risk/benefit if CrCl <50
hepatic dosing
- [see below]
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.