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Black Box Warnings .
Endometrial Cancer with Unopposed Estrogen in Patients with Intact Uterus
unopposed estrogen use incr. risk of endometrial CA in patients with intact uterus; adding progestogen has been shown to decr. risk of endometrial hyperplasia, a possible precursor to endometrial CA; perform adequate diagnostic measures (including directed or random endometrial sampling) to rule out malignancy in menopausal patient with abnormal genital bleeding of unknown etiology
Adult Dosing .
Dosage forms: TAB: 1 mg/5 mcg
vasomotor symptoms, moderate-severe menopausal
- [1 tab PO qd]
- Info: use lowest effective estrogen dose, shortest effective tx duration
osteoporosis prevention, postmenopausal
- [1 tab PO qd]
- Info: calcium and vitamin D supplementation recommended; weigh estrogen tx risk/benefit; fixed-dose regimen may not contain lowest effective estrogen dose
renal dosing
- [see below]
- renal disease: not defined, caution advised
- HD/PD: not defined, caution advised
hepatic dosing
- [see below]
- hepatic impairment/disease: contraindicated
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.