Xgeva

Adult Dosing .

Dosage forms:  INJ: 120 mg per 1.7 mL

bone metastases, solid tumor-associated

[120 mg SC q4wk]

Info: for skeletal-related events prevention; calcium and vitamin D supplementation recommended

skeletal-related event prevention, multiple myeloma-associated

[120 mg SC q4wk]

Info: calcium and vitamin D supplementation recommended

giant cell tumor of bone, unresectable

[120 mg SC q4wk]

Start: 120 mg SC qwk x3wk, then starting wk 5, 120 mg SC q4wk; Info: calcium and vitamin D supplementation recommended

hypercalcemia, malignant

[120 mg SC q4wk]

Start: 120 mg SC qwk x3wk, then starting wk 5, 120 mg SC q4wk

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ: 120 mg per 1.7 mL

giant cell tumor of bone, unresectable

[adolescents w/ skeletal maturity]

Dose: 120 mg SC q4wk; Start: 120 mg SC qwk x3wk, then starting wk 5, 120 mg SC q4wk; Info: calcium and vitamin D supplementation recommended

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[not defined]