Dopram

Adult Dosing .

Dosage forms:  INJ

respiratory depression, postanesthesia

[intermittent injection]

Dose: 0.5-1 mg/kg/dose IV q5min prn; Max: 1.5 mg/kg/single dose, 2 mg/kg/total dose, 3 g/24h

[intermittent infusion]

Dose: 0.5-1 mg/kg/dose IV; Max: 4 mg/kg/dose, 3 g/24h; Info: give 5 mg/min IV until response, then 1-3 mg/min IV up to 2h

CNS depression, drug-induced

[intermittent injection]

Dose: 1-2 mg/kg/dose IV q1-2h prn; Start: 1-2 mg/kg/dose IV q5min x2 doses; Max: 3 g/24h

[intermittent infusion]

Dose: 1-3 mg/kg/h IV up to 2h; Start: 1-2 mg/kg/dose IV q5min x2 doses; Max: 3 g/24h; Info: if no response to start doses, may repeat start in 1-2h

acute hypercapnia, COPD-assoc.

[1-3 mg/min IV up to 2h]

Start: 1-2 mg/min IV; Max: 3 mg/min, 3 g/24h

renal dosing

[see below]

renal impairment: not defined; Info: caution advised if significant impairment

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined; Info: caution advised if significant impairment

Peds Dosing .

Dosage forms:  INJ

respiratory depression, postanesthesia

[intermittent injection, 12 yo and older]

Dose: 0.5-1 mg/kg/dose IV q5min prn; Max: 1.5 mg/kg/single dose, 2 mg/kg/total dose, 3 g/24h

[intermittent infusion, 12 yo and older]

Dose: 0.5-1 mg/kg/dose IV; Max: 4 mg/kg/dose, 3 g/24h; Info: give 5 mg/min IV until response, then 1-3 mg/min IV up to 2h

CNS depression, drug-induced

[intermittent injection, 12 yo and older]

Dose: 1-2 mg/kg/dose IV q1-2h prn; Start: 1-2 mg/kg/dose IV q5min x2 doses; Max: 3 g/24h

[intermittent infusion, 12 yo and older]

Dose: 1-3 mg/kg/h IV up to 2h; Start: 1-2 mg/kg/dose IV q5min x2 doses; Max: 3 g/24h; Info: if no response to start doses, may repeat start in 1-2h

renal dosing

[see below]

renal impairment: not defined; Info: caution advised if significant impairment

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined; Info: caution advised if significant impairment