Select a medication above to begin.
deferiprone
generic
Black Box Warnings .
Agranulocytosis/Neutropenia
may occur and lead to serious infections and death; neutropenia may precede agranulocytosis; measure ANC at baseline, then qwk; interrupt tx if ANC <1500 cells/mm^3; interrupt tx if infection develops and monitor ANC more frequently; advise pts to promptly report any sx of infection
Adult Dosing .
Dosage forms: TAB: 500 mg
iron overload, chronic transfusional
- [25-33 mg/kg/dose PO tid]
- Start: 25 mg/kg/dose PO tid; Max: 99 mg/kg/day; Alt: start 15 mg/kg/dose PO tid, incr. by 5 mg/kg/dose qwk; Info: for pts w/ thalassemia syndromes, sickle cell dz, or other transfusion-dependent anemias; round dose to nearest half-tab; adjust dose q2-3mo based on serum ferritin levels; may interrupt tx if serum ferritin levels consistently <500 mcg/L; interrupt tx if ANC <1500
renal dosing
- [see below]
- eGFR >15: no adjustment; eGFR <15: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined
Peds Dosing .
- Dosage forms: TAB: 500 mg
iron overload, chronic transfusional
- [8 yo and older]
- Dose: 25-33 mg/kg/dose PO tid; Start: 25 mg/kg/dose PO tid; Max: 99 mg/kg/day; Alt: start 15 mg/kg/dose PO tid, incr. by 5 mg/kg/dose qwk; Info: for pts w/ thalassemia syndromes, sickle cell dz, or other transfusion-dependent anemias; round dose to nearest half-tab; adjust dose q2-3mo based on serum ferritin levels; may interrupt tx if serum ferritin levels consistently <500 mcg/L; interrupt tx if ANC <1500
renal dosing
- [see below]
- eGFR >15: no adjustment; eGFR <15: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined