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Linzess
linaclotide
Black Box Warnings .
Pediatric Risk
contraindicated in patients <2 yo; deaths occurred due to dehydration within 24h in nonclinical studies in neonatal mice after administration of a single clinically relevant adult oral dose
Adult Dosing .
Dosage forms: CAP: 72 mcg, 145 mcg, 290 mcg
IBS, constipation-predominant
- [290 mcg PO/NG/GT qd]
- Info: give at least 30min before meal; may open cap, but do not crush/chew contents
chronic idiopathic constipation
- [145 mcg PO/NG/GT qd]
- Info: may give 72 mcg PO/NG/GT qd if tolerability concern; give at least 30min before meal; may open cap, but do not crush/chew contents
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [no adjustment]
Peds Dosing .
- Dosage forms: CAP: 72 mcg
IBS, constipation-predominant
- [7 yo and older]
- Dose: 145 mcg PO/NG/GT qd; Info: give at least 30min before meal; may open cap, but do not crush/chew contents
functional constipation
- [6 yo and older]
- Dose: 72 mcg PO/NG/GT qd; Info: give at least 30min before meal; may open cap, but do not crush/chew contents
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [no adjustment]