Astagraf XL

Adult Dosing .

Dosage forms:  ER CAP: 0.5 mg, 1 mg, 5 mg

Special Note

[equivalency or interchangeability info]

Info: tacrolimus ER products not interchangeable w/ other ER or IR products; do not substitute on a mg to mg basis

kidney transplant rejection prophylaxis

[w/ basiliximab induction tx]

Dose: 0.15-0.2 mg/kg/dose PO qam; Start: before reperfusion or w/in 48h post-transplant; Info: adjust dose based on serum levels; give on empty stomach; do not open/crush/chew cap

[w/o basiliximab induction tx]

Dose: 0.2 mg/kg/dose PO qam; Start: 0.1 mg/kg/dose PO x1 preop and w/in 12h before reperfusion; Info: give initial maint. dose postop >4h after preop dose and w/in 12h after reperfusion; Info: adjust dose based on serum levels; give on empty stomach; do not open/crush/chew cap

renal dosing

[see below]

renal impairment: give lowest recommended dose, may consider further dose decr.

HD/PD: not defined

hepatic dosing

[see below]

mild impairment: no adjustment; moderate impairment: not defined; severe impairment: consider decr. usual dose

Peds Dosing .

Dosage forms:  ER CAP: 0.5 mg, 1 mg, 5 mg

Special Note

[equivalency or interchangeability info]

Info: tacrolimus ER products not interchangeable w/ other ER or IR products; do not substitute on a mg to mg basis

kidney transplant rejection prophylaxis

[w/ basiliximab induction tx, 4 yo and older]

Dose: 0.3 mg/kg/dose PO qam; Start: w/in 24h after reperfusion; Info: adjust dose based on serum levels; give on empty stomach; do not open/crush/chew cap

renal dosing

[see below]

renal impairment: give lowest recommended dose, may consider further dose decr.

HD/PD: not defined

hepatic dosing

[see below]

mild impairment: no adjustment; moderate impairment: not defined; severe impairment: consider decr. usual dose