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Opsumit
macitentan
Black Box Warnings .
Embryo-Fetal Toxicity
contraindicated in pregnancy due to risk of fetal harm; exclude pregnancy prior to tx initiation; avoid pregnancy by using effective methods of contraception prior to tx start, during tx, and x1mo after D/C; D/C ASAP if pregnancy detected
Adult Dosing .
Dosage forms: TAB: 10 mg
pulmonary arterial HTN
- [10 mg PO qd]
- Max: 10 mg/day
renal dosing
- [see below]
- CrCl >15: no adjustment; CrCl <15: not defined
- HD/PD: not defined
hepatic dosing
- [no adjustment]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.