Select a medication above to begin.
Otezla
apremilast
Adult Dosing .
Dosage forms: TAB: 30 mg; TAB (28-day initiation pack): 10 mg x4, 20 mg x4, and 30 mg x47
Special Note
- [equivalency or interchangeability info]
- Info: apremilast IR and ER products not interchangeable; do not substitute on a mg to mg basis
psoriatic arthritis
- [30 mg PO bid]
- Start: 10 mg PO qam x1 day, then 10 mg PO bid x1 day, then 10 mg PO qam and 20 mg PO qpm x1 day, then 20 mg PO bid x1 day, then 20 mg PO qam and 30 mg PO qpm x1 day, then 30 mg PO bid; Info: do not cut/crush/chew tab
psoriasis, plaque
- [30 mg PO bid]
- Start: 10 mg PO qam x1 day, then 10 mg PO bid x1 day, then 10 mg PO qam and 20 mg PO qpm x1 day, then 20 mg PO bid x1 day, then 20 mg PO qam and 30 mg PO qpm x1 day, then 30 mg PO bid; Info: do not cut/crush/chew tab
oral ulcers, Behcet disease-associated
- [30 mg PO bid]
- Start: 10 mg PO qam x1 day, then 10 mg PO bid x1 day, then 10 mg PO qam and 20 mg PO qpm x1 day, then 20 mg PO bid x1 day, then 20 mg PO qam and 30 mg PO qpm x1 day, then 30 mg PO bid; Info: do not cut/crush/chew tab
renal dosing
- [adjust dose frequency]
- CrCl <30: start 10 mg qam x3 days, then 20 mg qam x2 days, then 30 mg qd
- HD/PD: not defined
hepatic dosing
- [no adjustment]
Peds Dosing .
- Dosage forms: TAB: 20 mg, 30 mg; TAB (20 mg dose 28-day initiation pack): 10 mg x4 and 20 mg x51; TAB (30 mg dose 28-day initiation pack): 10 mg x4, 20 mg x4, and 30 mg x47
Special Note
- [equivalency or interchangeability info]
- Info: apremilast IR and ER products not interchangeable; do not substitute on a mg to mg basis
psoriatic arthritis
- [6 yo and older, 20-49.9 kg]
- Dose: 20 mg PO bid; Start: 10 mg PO qam x1 day, then 10 mg PO bid x1 day, then 10 mg PO qam and 20 mg PO qpm x1 day, then 20 mg PO bid; Info: do not cut/crush/chew tab
- [6 yo and older, >50 kg]
- Dose: 30 mg PO bid; Start: 10 mg PO qam x1 day, then 10 mg PO bid x1 day, then 10 mg PO qam and 20 mg PO qpm x1 day, then 20 mg PO bid x1 day, then 20 mg PO qam and 30 mg PO qpm x1 day, then 30 mg PO bid; Info: do not cut/crush/chew tab
psoriasis, moderate-severe plaque
- [6 yo and older, 20-49.9 kg]
- Dose: 20 mg PO bid; Start: 10 mg PO qam x1 day, then 10 mg PO bid x1 day, then 10 mg PO qam and 20 mg PO qpm x1 day, then 20 mg PO bid; Info: do not cut/crush/chew tab
- [6 yo and older, >50 kg]
- Dose: 30 mg PO bid; Start: 10 mg PO qam x1 day, then 10 mg PO bid x1 day, then 10 mg PO qam and 20 mg PO qpm x1 day, then 20 mg PO bid x1 day, then 20 mg PO qam and 30 mg PO qpm x1 day, then 30 mg PO bid; Info: do not cut/crush/chew tab
renal dosing
- [20-49.9 kg]
- CrCl <30: start 10 mg qam x3 days, then 20 mg qd
- HD/PD: not defined
- [>50 kg]
- CrCl <30: start 10 mg qam x3 days, then 20 mg qam x2 days, then 30 mg qd
- HD/PD: not defined
hepatic dosing
- [no adjustment]