Otezla

Adult Dosing .

Dosage forms:  TAB: 30 mg; 28-day convenience pack

Dosage Form Details

[28-day (30 mg bid dose) convenience pack components]

Info: 28-day starter pack contains 10 mg tab x4 and 20 mg tab x4 and 30 mg tab x47

psoriatic arthritis

[30 mg PO bid]

Start: 10 mg PO qam x1 day, then 10 mg PO bid x1 day, then 10 mg PO qam and 20 mg PO qpm x1 day, then 20 mg PO bid x1 day, then 20 mg PO qam and 30 mg PO qpm x1 day, then 30 mg PO bid; Info: do not cut/crush/chew tab

psoriasis, plaque

[30 mg PO bid]

Start: 10 mg PO qam x1 day, then 10 mg PO bid x1 day, then 10 mg PO qam and 20 mg PO qpm x1 day, then 20 mg PO bid x1 day, then 20 mg PO qam and 30 mg PO qpm x1 day, then 30 mg PO bid; Info: do not cut/crush/chew tab

oral ulcers, Behcet dz-assoc.

[30 mg PO bid]

Start: 10 mg PO qam x1 day, then 10 mg PO bid x1 day, then 10 mg PO qam and 20 mg PO qpm x1 day, then 20 mg PO bid x1 day, then 20 mg PO qam and 30 mg PO qpm x1 day, then 30 mg PO bid; Info: do not cut/crush/chew tab

renal dosing

[adjust dose frequency]

CrCl <30: start 10 mg qam x3 days, then 20 mg qam x2 days, then 30 mg qd

HD/PD: not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  TAB: 20 mg, 30 mg; 28-day convenience packs

Dosage Form Details

[28-day (20 mg bid dose) convenience pack components]

Info: 28-day starter pack contains 10 mg tab x4 and 20 mg tab x51

[28-day (30 mg bid dose) convenience pack components]

Info: 28-day starter pack contains 10 mg tab x4 and 20 mg tab x4 and 30 mg tab x47

psoriatic arthritis

[6 yo and older, 20-49.9 kg]

Dose: 20 mg PO bid; Start: 10 mg PO qam x1 day, then 10 mg PO bid x1 day, then 10 mg PO qam and 20 mg PO qpm x1 day, then 20 mg PO bid; Info: do not cut/crush/chew tab

[6 yo and older, >50 kg]

Dose: 30 mg PO bid; Start: 10 mg PO qam x1 day, then 10 mg PO bid x1 day, then 10 mg PO qam and 20 mg PO qpm x1 day, then 20 mg PO bid x1 day, then 20 mg PO qam and 30 mg PO qpm x1 day, then 30 mg PO bid; Info: do not cut/crush/chew tab

psoriasis, mod-severe plaque

[6 yo and older, 20-49.9 kg]

Dose: 20 mg PO bid; Start: 10 mg PO qam x1 day, then 10 mg PO bid x1 day, then 10 mg PO qam and 20 mg PO qpm x1 day, then 20 mg PO bid; Info: do not cut/crush/chew tab

[6 yo and older, >50 kg]

Dose: 30 mg PO bid; Start: 10 mg PO qam x1 day, then 10 mg PO bid x1 day, then 10 mg PO qam and 20 mg PO qpm x1 day, then 20 mg PO bid x1 day, then 20 mg PO qam and 30 mg PO qpm x1 day, then 30 mg PO bid; Info: do not cut/crush/chew tab

renal dosing

[20-49.9 kg]

CrCl <30: start 10 mg qam x3 days, then 20 mg qd

HD/PD: not defined

[>50 kg]

CrCl <30: start 10 mg qam x3 days, then 20 mg qam x2 days, then 30 mg qd

HD/PD: not defined

hepatic dosing

[no adjustment]