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Impavido
miltefosine
Black Box Warnings .
Embryo-Fetal Toxicity
contraindicated in pregnancy; fetal harm occurred in animal studies; verify pregnancy status before initiating tx and use effective contraception during tx and x5mo after D/C in pts of childbearing potential
Adult Dosing .
Dosage forms: CAP: 50 mg
visceral leishmaniasis
- [30-44 kg]
- Dose: 50 mg PO bid x28 days; Info: give w/ meals
- [>45 kg]
- Dose: 50 mg PO tid x28 days; Info: give w/ meals
cutaneous leishmaniasis
- [30-44 kg]
- Dose: 50 mg PO bid x28 days; Info: give w/ meals
- [>45 kg]
- Dose: 50 mg PO tid x28 days; Info: give w/ meals
mucosal leishmaniasis
- [30-44 kg]
- Dose: 50 mg PO bid x28 days; Info: give w/ meals
- [>45 kg]
- Dose: 50 mg PO tid x28 days; Info: give w/ meals
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: CAP: 50 mg
visceral leishmaniasis
- [12 yo and older, 30-44 kg]
- Dose: 50 mg PO bid x28 days; Info: give w/ meals
- [12 yo and older, >45 kg]
- Dose: 50 mg PO tid x28 days; Info: give w/ meals
cutaneous leishmaniasis
- [12 yo and older, 30-44 kg]
- Dose: 50 mg PO bid x28 days; Info: give w/ meals
- [12 yo and older, >45 kg]
- Dose: 50 mg PO tid x28 days; Info: give w/ meals
mucosal leishmaniasis
- [12 yo and older, 30-44 kg]
- Dose: 50 mg PO bid x28 days; Info: give w/ meals
- [12 yo and older, >45 kg]
- Dose: 50 mg PO tid x28 days; Info: give w/ meals
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised