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Diseases

Keloid

OVERVIEW

  • Highlights & Basics
  • Images

DIAGNOSIS

  • Diagnostic Approach
  • Risk Factors
  • History & Exam
  • Tests
  • Differential Diagnosis
  • Criteria
  • Screening

TREATMENT

  • Tx Approach
  • Tx Options
  • Emerging Tx
  • Prevention

FOLLOW-UP

  • Overview
  • Complications

REFERENCES

  • Citations
  • Guidelines
  • Credits

PATIENT RESOURCES

  • Patient Instructions

Highlights & Basics

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Key Highlights
  • Keloid is a form of abnormal scarring that occurs in susceptible individuals.

  • More common in darker skin types.

  • Diagnosis is clinical.

  • Treatment options include injectable preparations, cryotherapy, as well as surgery and radiation therapy.

Stable keloid due to ear piercing
Stable keloid due to ear piercing
From the collection of Professor Andrew Burd, used with permission

Quick Reference

  • History & Exam

    • Key Factors

      • Other Factors

        More information...
      • Diagnostics Tests

          More information...
        • Treatment Options

            More information...

          Definition

          Epidemiology

          Etiology

          Pathophysiology

          content by BMJ Group
          Last updated

          Images

          • Elevated, red, smooth, nodule of scar tissue; arose in the site of an acne lesion that had been sque

            Elevated, red, smooth, nodule of scar tissue; arose in the site of an acne lesion that had been squeezed

          • Red, elevated keloid; edges blend into the surrounding skin; arose in a vaccination site in the left

            Red, elevated keloid; edges blend into the surrounding skin; arose in a vaccination site in the left upper arm

          • An extensive keloid has been previously excised and the defect skin grafted; keloid scarring has sub

            An extensive keloid has been previously excised and the defect skin grafted; keloid scarring has subsequently developed at the peripheries

          • The timelines for normal, hypertrophic, and keloid scar formation. Keloid scarring is different in t

            The timelines for normal, hypertrophic, and keloid scar formation. Keloid scarring is different in that it does not mature (involute); expansion may occur but, in contrast to hypertrophic scarring, contraction does not occur either in the scar or in the surrounding tissue

          • Stable keloid due to ear piercing

            Stable keloid due to ear piercing

          • A typical presternal keloid; presence of central bridging, an elevated rolled edge and flattened per

            A typical presternal keloid; presence of central bridging, an elevated rolled edge and flattened peripheral extensions

          • Keloid reaction following a vaccination in the deltoid region; following surgical excision the entir

            Keloid reaction following a vaccination in the deltoid region; following surgical excision the entire length of the scar developed a keloid-like appearance

          • A hypertrophic scar before excision to correct contraction deformity following a burn

            A hypertrophic scar before excision to correct contraction deformity following a burn

          • Contraction deformity of little finger corrected by excision

            Contraction deformity of little finger corrected by excision

          Citations

            Key Articles

            • Ogawa R. The most current algorithms for the treatment and prevention of hypertrophic scars and keloids: a 2020 update of the algorithms published 10 years ago. Plast Reconstr Surg. 2022 Jan 1;149(1):79e-94e.[Abstract][Full Text]

            • Ogawa R, Akita S, Akaishi S, et al. Diagnosis and treatment of keloids and hypertrophic scars - Japan Scar Workshop consensus document 2018. Burns Trauma. 2019;7:39.[Abstract]

            • Gold MH, Berman B, Clementoni MT, et al. Updated international clinical recommendations on scar management: part 1 - evaluating the evidence. Dermatol Surg. 2014 Aug;40(8):817-24.[Abstract]

            • Royal College of Radiologists. Recommendations for using radiotherapy for benign disease in the UK. 2023 [internet publication].[Full Text]

            Referenced Articles

            • 1. Ogawa R. Keloid and hypertrophic scars are the result of chronic inflammation in the reticular dermis. Int J Mol Sci. 2017 Mar 10;18(3):606.[Abstract][Full Text]

            • 2. Limandjaja GC, Niessen FB, Scheper RJ, et al. The keloid disorder: heterogeneity, histopathology, mechanisms and models. Front Cell Dev Biol. 2020;8:360.[Abstract][Full Text]

            • 3. ​Huang C, Wu Z, Du Y, Ogawa R. The epidemiology of keloids. In: Téot L, Mustoe TA, Middelkoop E, et al., eds. Textbook on scar management: state of the art management and emerging technologies [Internet]. Cham: Springer; 2020.[Abstract][Full Text]

            • 4. Ung CY, Warwick A, Onoufriadis A, et al. Comorbidities of keloid and hypertrophic scars among participants in UK biobank. JAMA Dermatol. 2023 Feb 1;159(2):172-81.[Abstract][Full Text]

            • 5. Tulandi T, Al-Sannan B, Akbar G, et al. Prospective study of intraabdominal adhesions among women of different races with or without keloids. Am J Obstet Gynecol. 2011 Feb;204(2):132.e1-4.[Abstract][Full Text]

            • 6. Bayat A, Arscott G, Ollier WE, et al. Keloid disease: clinical relevance of single versus multiple site scars. Br J Plast Surg. 2005 Jan;58(1):28-37.[Abstract]

            • 7. Ogawa R. Keloid and hypertrophic scarring may result from a mechanoreceptor or mechanosensitive nociceptor disorder. Med Hypotheses. 2008 Oct;71(4):493-500.[Abstract]

            • 8. Akaishi S, Akimoto M, Ogawa R, et al. The relationship between keloid growth pattern and stretching tension: visual analysis using the finite element method. Ann Plast Surg. 2008 Apr;60(4):445-51.[Abstract]

            • 9. Kiprono SK, Chaula BM, Masenga JE, et al. Epidemiology of keloids in normally pigmented Africans and African people with albinism: population-based cross-sectional survey. Br J Dermatol. 2015 Sep;173(3):852-4.[Abstract]

            • 10. Nakashima M, Chung S, Takahashi A, et al. A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population. Nat Genet. 2010 Sep;42(9):768-71.[Abstract]

            • 11. Marneros AG, Norris JE, Watanabe S, et al. Genome scans provide evidence for keloid susceptibility loci on chromosomes 2q23 and 7p11. J Invest Dermatol. 2004 May;122(5):1126-32.[Abstract][Full Text]

            • 12. Chen Y, Gao JH, Yan X, et al. [Location of predisposing gene for one Han Chinese keloid pedigree]. [in chi]. Zhonghua Zheng Xing Wai Ke Za Zhi. 2007 Mar;23(2):137-40.[Abstract]

            • 13. Robles DT, Moore E, Draznin M, et al. Keloids: pathophysiology and management. Dermatology Online J. 2007 Jul 13;13(3):9.[Abstract][Full Text]

            • 14. Butler PD, Longaker MT, Yang GP. Current progress in keloid research and treatment. J Am Coll Surg. 2008 Apr;206(4):731-41.[Abstract]

            • 15. Mari W, Alsabri SG, Tabal N, et al. Novel insights on understanding of keloid scar: article review. J Am Coll Clin Wound Spec. 2016 Nov 30;7(1-3):1-7.[Abstract][Full Text]

            • 16. Gauglitz GG, Korting HC, Pavicic T, et al. Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. Mol Med. 2011 Jan-Feb;17(1-2):113-25.[Abstract][Full Text]

            • 17. Ogawa R. The most current algorithms for the treatment and prevention of hypertrophic scars and keloids: a 2020 update of the algorithms published 10 years ago. Plast Reconstr Surg. 2022 Jan 1;149(1):79e-94e.[Abstract][Full Text]

            • 18. Burd A, Huang L. Hypertrophic response and keloid diathesis: two very different forms of scar. Plast Reconstr Surg. 2005 Dec;116(7):150e-7e.[Abstract]

            • 19. Knowles A, Glass DA 2nd. Keloids and hypertrophic scars. Dermatol Clin. 2023 Jul;41(3):509-17.[Abstract]

            • 20. Ogawa R, Okai K, Tokumura F, et al. The relationship between skin stretching/contraction and pathologic scarring: the important role of mechanical forces in keloid generation. Wound Repair Regen. 2012 Mar-Apr;20(2):149-57.[Abstract]

            • 21. Ogawa R, Akita S, Akaishi S, et al. Diagnosis and treatment of keloids and hypertrophic scars - Japan Scar Workshop consensus document 2018. Burns Trauma. 2019;7:39.[Abstract]

            • 22. Ogawa R, Akaishi S, Hyakusoku H. Differential and exclusive diagnosis of diseases that resemble keloids and hypertrophic scars. Ann Plast Surg. 2009 Jun;62(6):660-4.[Abstract][Full Text]

            • 23. Nguyen CM, Burch JM, Fitzpatrick JE, et al. Giant cell fibroblastoma in a child misdiagnosed as a dermatofibroma. Pediatr Dermatol. 2002 Jan-Feb;19(1):28-32.[Abstract]

            • 24. Durani P, Bayat A. Levels of evidence for the treatment of keloid disease. J Plast Reconstr Aesthet Surg. 2008;61(1):4-17.[Abstract]

            • 25. Elsaie ML. Update on management of keloid and hypertrophic scars: a systemic review. J Cosmet Dermatol. 2021 Sep;20(9):2729-38.[Abstract]

            • 26. Wolfram D, Tzankov A, Pülzl P, et al. Hypertrophic scars and keloids - a review of their pathophysiology, risk factors, and therapeutic management. Dermatol Surg. 2009 Feb;35(2):171-81.[Abstract][Full Text]

            • 27. Guthmann R, Williams CC, De Groote S. Clinical inquiry: what treatment is best for hypertrophic scars and keloids? J Fam Pract. 2011 Dec;60(12):757-8.[Abstract]

            • 28. Lv K, Xia Z, Chinese consensus panel on the prevention and treatment of scars. Chinese expert consensus on clinical prevention and treatment of scar. Burns Trauma. 2018;6:27.[Abstract][Full Text]

            • 29. Gold MH, Berman B, Clementoni MT, et al. Updated international clinical recommendations on scar management: part 1 - evaluating the evidence. Dermatol Surg. 2014 Aug;40(8):817-24.[Abstract]

            • 30. Ren Y, Zhou X, Wei Z, et al. Efficacy and safety of triamcinolone acetonide alone and in combination with 5-fluorouracil for treating hypertrophic scars and keloids: a systematic review and meta-analysis. Int Wound J. 2017 Jun;14(3):480-7.[Abstract][Full Text]

            • 31. Kang N, Sivakumar B, Sanders R, et al. Intra-lesional injections of collagenase are ineffective in the treatment of keloid and hypertrophic scars. J Plast Reconstr Aesthet Surg. 2006;59(7):693-9.[Abstract]

            • 32. McCoy BJ, Diegelmann RF, Cohen IK. In vitro inhibition of cell growth, collagen synthesis, and prolyl hydroxylase activity by triamcinolone acetonide. Proc Soc Exp Biol Med. 1980 Feb;163(2):216-22.[Abstract]

            • 33. Morelli Coppola M, Salzillo R, Segreto F, et al. Triamcinolone acetonide intralesional injection for the treatment of keloid scars: patient selection and perspectives. Clin Cosmet Investig Dermatol. 2018;11:387-96.[Abstract][Full Text]

            • 34. Yin Q, Niessen FB, Gibbs S, et al. Intralesional corticosteroid administration in the treatment of keloids: a survey among Dutch dermatologists and plastic surgeons. J Dermatolog Treat. 2023 Dec;34(1):2159308.[Abstract][Full Text]

            • 35. Fredman R, Tenenhaus M. Cushing's syndrome after intralesional triamcinolone acetonide: a systematic review of the literature and multinational survey. Burns. 2013 Jun;39(4):549-57.[Abstract][Full Text]

            • 36. Darzi MA, Chowdri NA, Kaul SK, et al. Evaluation of various methods of treating keloids and hypertrophic scars: a 10-year follow-up study. Br J Plast Surg. 1992 Jul;45(5):374-9.[Abstract][Full Text]

            • 37. Jalali M, Bayat A. Current use of steroids in management of abnormal raised skin scars. Surgeon. 2007 Jun;5(3):175-80.[Abstract]

            • 38. Gold MH, McGuire M, Mustoe TA, et al. Updated international clinical recommendations on scar management: part 2 - algorithms for scar prevention and treatment. Dermatol Surg. 2014 Aug;40(8):825-31.[Abstract]

            • 39. Martinsson T, Haegerstrand A, Dalsgaard CJ. Ropivacaine and lidocaine inhibit proliferation of non-transformed cultured adult human fibroblasts, endothelial cells, and keratinocytes. Agents Actions. 1993 Sep;40(1-2):78-85.[Abstract]

            • 40. Eichhorn JH, Peterkofsky B. Local anesthetic-induced inhibition of collagen secretion in cultured cells under conditions where microtubules are not depolymerized by these agents. J Cell Biol. 1979 Apr;81(1):26-42.[Abstract][Full Text]

            • 41. Goutos I, Ogawa R. Steroid tape: A promising adjunct to scar management. Scars Burn Heal. 2017 Jan-Dec;3:2059513117690937.[Abstract][Full Text]

            • 42. Goldman L, Igelman JM, Kitzmiller KW. Clinical investigative studies with flurandrenolone tape. Cutis 1967; 3: 367-71.

            • 43. Ratzer MA. A clinical trial of flurandrenolone tape. Br J Clin Pract. 1970 Apr;24(4):185-9.[Abstract]

            • 44. ​Ogawa R. Effectiveness of corticosteroid tapes and plasters for keloids and hypertrophic scars. In: Téot L, Mustoe TA, Middelkoop E, et al., eds. Textbook on scar management: state of the art management and emerging technologies [Internet]. Cham: Springer; 2020. [Abstract]

            • 45. Nast A, Gauglitz G, Lorenz K, et al. S2k guidelines for the therapy of pathological scars (hypertrophic scars and keloids) - update 2020. J Dtsch Dermatol Ges. 2021 Feb;19(2):312-27.[Abstract][Full Text]

            • 46. ​Yii NW and Frame JD. Evaluation of cynthaskin and topical steroid in the treatment of hypertrophic scars and keloids. Eur J Plast Surg 1996;19:162-5.

            • 47. Marsden CW. Fluocinolone acetonide 0.2 per cent cream - a co-operative clinical trial. Br J Dermatol. 1968 Sep;80(9):614-7.[Abstract]

            • 48. Shah VV, Aldahan AS, Mlacker S, et al. 5-Fluorouracil in the treatment of keloids and hypertrophic scars: a comprehensive review of the literature. Dermatol Ther (Heidelb). 2016 Jun;6(2):169-83.[Abstract][Full Text]

            • 49. Bijlard E, Steltenpool S, Niessen FB. Intralesional 5-fluorouracil in keloid treatment: a systematic review. Acta Derm Venereol. 2015 Sep;95(7):778-82.[Abstract][Full Text]

            • 50. Saha AK, Mukhopadhyay M. A comparative clinical study on role of 5-flurouracil versus triamcinolone in the treatment of keloids. Indian J Surg. 2012 Aug;74(4):326-9.[Abstract][Full Text]

            • 51. ​Prabhu A, Sreekar H, Powar R, et al. A randomized controlled trial comparing the efficacy of intralesional 5-fluorouracil versus triamcinolone acetonide in the treatment of keloids. J Sci Soc. 2012;39:19-25.[Full Text]

            • 52. Asilian A, Darougheh A, Shariati F. New combination of triamcinolone, 5-fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars. Dermatol Surg. 2006 Jul;32(7):907-15.[Abstract]

            • 53. Chen XE, Liu J, Bin Jameel AA, et al. Combined effects of long-pulsed neodymium-yttrium-aluminum-garnet laser, diprospan and 5-fluorouracil in the treatment of keloid scars. Exp Ther Med. 2017 Jun;13(6):3607-12.[Abstract][Full Text]

            • 54. Davison SP, Dayan JH, Clemens MW, et al. Efficacy of intralesional 5-fluorouracil and triamcinolone in the treatment of keloids. Aesthet Surg J. 2009 Jan-Feb;29(1):40-6.[Abstract][Full Text]

            • 55. Kim WI, Kim S, Cho SW, et al. The efficacy of bleomycin for treating keloid and hypertrophic scar: a systematic review and meta-analysis. J Cosmet Dermatol. 2020 Dec;19(12):3357-66.[Abstract]

            • 56. Shin JY, Yun SK, Roh SG, et al. Efficacy of 2 representative topical agents to prevent keloid recurrence after surgical excision. J Oral Maxillofac Surg. 2017 Feb;75(2):401.e1-401.e6.[Abstract]

            • 57. Khansa I, Harrison B, Janis JE. Evidence-based scar management: how to improve results with technique and technology. Plast Reconstr Surg. 2016 Sep;138(3 suppl):165S-78S.[Abstract]

            • 58. Kuo YR, Wu WS, Jeng SF, et al. Suppressed TGF-beta1 expression is correlated with up-regulation of matrix metalloproteinase-13 in keloid regression after flashlamp pulsed-dye laser treatment. Lasers Surg Med. 2005 Jan;36(1):38-42.[Abstract]

            • 59. Bouzari N, Davis SC, Nouri K, et al. Laser treatment of keloids and hypertrophic scars. Int J Dermatol. 2007 Jan;46(1):80-8.[Abstract]

            • 60. de las Alas JM, Siripunvarapon AH, Dofitas BL. Pulsed dye laser for the treatment of keloid and hypertrophic scars: a systematic review. Expert Rev Med Devices. 2012 Nov;9(6):641-50.[Abstract]

            • 61. Al-Mohamady Ael-S, Ibrahim SM, Muhammad MM. Pulsed dye laser versus long-pulsed Nd:YAG laser in the treatment of hypertrophic scars and keloid: a comparative randomized split-scar trial. J Cosmet Laser Ther. 2016 Aug;18(4):208-12.[Abstract]

            • 62. Rossi A, Lu R, Frey MK, et al. The use of the 300 microsecond 1064 nm Nd:YAG laser in the treatment of keloids. J Drugs Dermatol. 2013 Nov;12(11):1256-62.[Abstract]

            • 63. Leszczynski R, da Silva CA, Pinto ACPN, et al. Laser therapy for treating hypertrophic and keloid scars. Cochrane Database Syst Rev. 2022 Sep 26;9(9):CD011642.[Abstract][Full Text]

            • 64. Forbat E, Ali FR, Al-Niaimi F. Treatment of keloid scars using light-, laser- and energy-based devices: a contemporary review of the literature. Lasers Med Sci. 2017 Dec;32(9):2145-54.[Abstract]

            • 65. Apfelberg DB, Maser MR, White DN, et al. Failure of carbon dioxide laser excision of keloids. Lasers Surg Med. 1989;9(4):382-8.[Abstract]

            • 66. Connell PG, Harland CC. Treatment of keloid scars with pulsed dye laser and intralesional steroid. J Cutan Laser Ther. 2000 Sep;2(3):147-50.[Abstract]

            • 67. Garg GA, Sao PP, Khopkar US. Effect of carbon dioxide laser ablation followed by intralesional steroids on keloids. J Cutan Aesthet Surg. 2011 Jan;4(1):2-6.[Abstract][Full Text]

            • 68. Wang J, Wu J, Xu M, et al. Combination therapy of refractory keloid with ultrapulse fractional carbon dioxide (CO2) laser and topical triamcinolone in Asians-long-term prevention of keloid recurrence. Dermatol Ther. 2020 Nov;33(6):e14359.[Abstract]

            • 69. Cavalié M, Sillard L, Montaudié H, et al. Treatment of keloids with laser-assisted topical steroid delivery: a retrospective study of 23 cases. Dermatol Ther. 2015 Mar-Apr;28(2):74-8.[Abstract]

            • 70. Abd El-Dayem DH, Nada HA, Hanafy NS, et al. Laser-assisted topical steroid application versus steroid injection for treating keloids: a split side study. J Cosmet Dermatol. 2021 Jan;20(1):138-42.[Abstract]

            • 71. O'Boyle CP, Shayan-Arani H, Hamada MW. Intralesional cryotherapy for hypertrophic scars and keloids: a review. Scars Burn Heal. 2017 Jan-Dec;3:2059513117702162.[Abstract][Full Text]

            • 72. Mustoe TA, Cooter RD, Gold MH, et al. International clinical recommendations on scar management. Plast Reconstr Surg. 2002 Aug;110(2):560-71.[Abstract]

            • 73. Ogawa R, Akaishi S, Huang C, et al. Clinical applications of basic research that shows reducing skin tension could prevent and treat abnormal scarring: the importance of fascial/subcutaneous tensile reduction sutures and flap surgery for keloid and hypertrophic scar reconstruction. J Nippon Med Sch. 2011;78(2):68-76.[Abstract][Full Text]

            • 74. Goutos I. Intralesional excision as a surgical strategy to manage keloid scars: what's the evidence? Scars Burn Heal. 2019 Jan-Dec;5:2059513119867297.[Abstract][Full Text]

            • 75. Royal College of Radiologists. Recommendations for using radiotherapy for benign disease in the UK. 2023 [internet publication].[Full Text]

            • 76. Ogawa R, Tosa M, Dohi T, et al. Surgical excision and postoperative radiotherapy for keloids. Scars Burn Heal. 2019 Jan-Dec;5:2059513119891113.[Abstract][Full Text]

            • 77. Malaker K, Vijayraghavan K, Hodson I, et al. Retrospective analysis of treatment of unresectable keloids with primary radiation over 25 years. Clin Oncol (R Coll Radiol). 2004 Jun;16(4):290-8.[Abstract]

            • 78. McKeown SR, Hatfield P, Prestwich RJ, et al. Radiotherapy for benign disease; assessing the risk of radiation-induced cancer following exposure to intermediate dose radiation. Br J Radiol. 2015;88(1056):20150405.[Abstract][Full Text]

            • 79. O'Brien L, Jones DJ. Silicone gel sheeting for preventing and treating hypertrophic and keloid scars. Cochrane Database Syst Rev. 2013 Sep 12;(9):CD003826.[Abstract][Full Text]

            • 80. Tian F, Jiang Q, Chen J, et al. Silicone gel sheeting for treating keloid scars. Cochrane Database Syst Rev. 2023 Jan 3;1(1):CD013878.[Abstract][Full Text]

            • 81. de Oliveira GV, Nunes TA, Magna LA, et al. Silicone versus nonsilicone gel dressings: a controlled trial. Dermatol Surg. 2001 Aug;27(8):721-6.[Abstract]

            • 82. Lin YS, Ting PS, Hsu KC. Comparison of silicone sheets and paper tape for the management of postoperative scars: a randomized comparative study Adv Skin Wound Care. 2020 Jun;33(6):1-6.[Abstract][Full Text]

            • 83. Ekstein SF, Wyles SP, Moran SL, et al. Keloids: a review of therapeutic management. Int J Dermatol. 2021 Jun;60(6):661-71.[Abstract]

            • 84. Sohrabi C, Goutos I. The use of botulinum toxin in keloid scar management: a literature review. Scars Burn Heal. 2020 Jan-Dec;6:2059513120926628.[Abstract][Full Text]

            • 85. Alser OH, Goutos I. The evidence behind the use of platelet-rich plasma (PRP) in scar management: a literature review. Scars Burn Heal. 2018 Jan-Dec;4:2059513118808773.[Abstract][Full Text]

            • 86. Jones ME, Hardy C, Ridgway J. Keloid management: a retrospective case review on a new approach using surgical excision, platelet-rich plasma, and in-office superficial photon x-ray radiation therapy. Adv Skin Wound Care. 2016 Jul;29(7):303-7.[Abstract][Full Text]

            • 87. Jones ME, McLane J, Adenegan R, et al. Advancing keloid treatment: a novel multimodal approach to ear keloids. Dermatol Surg. 2017 Sep;43(9):1164-9.[Abstract]

            • 88. Hersant B, SidAhmed-Mezi M, Picard F, et al. Efficacy of autologous platelet concentrates as adjuvant therapy to surgical excision in the treatment of keloid scars refractory to conventional treatments: a pilot prospective study. Ann Plast Surg. 2018 Aug;81(2):170-5.[Abstract]

            • 89. Hewedy ES, Sabaa BEI, Mohamed WS, et al. Combined intralesional triamcinolone acetonide and platelet rich plasma versus intralesional triamcinolone acetonide alone in treatment of keloids. J Dermatolog Treat. 2022 Feb;33(1):150-6.[Abstract]

            • 90. Bandyopadhyay B, Fan J, Guan S, et al. A "traffic control" role for TGFbeta3: orchestrating dermal and epidermal cell motility during wound healing. J Cell Biol. 2006 Mar 27;172(7):1093-105.[Abstract]

            • 91. Liebl H, Kloth LC. Skin cell proliferation stimulated by microneedles. J Am Coll Clin Wound Spec. 2012 Mar;4(1):2-6.[Abstract][Full Text]

            • 92. Fabbrocini G, Marasca C, Ammad S, et al. Assessment of the combined efficacy of needling and the use of silicone gel in the treatment of C-section and other surgical hypertrophic scars and keloids. Adv Skin Wound Care. 2016 Sep;29(9):408-11.[Abstract]

            • 93. Iosifidis C, Goutos I. Percutaneous collagen induction (microneedling) for the management of non-atrophic scars: literature review. Scars Burn Heal. 2019 Jan-Dec;5:2059513119880301.[Abstract][Full Text]

            • 94. Lu W, Chu H, Zheng X. Effects on quality of life and psychosocial wellbeing in Chinese patients with keloids. Am J Transl Res. 2021;13(3):1636-42.[Abstract][Full Text]

            • 95. Liang Z, Zhang M, Hao Y, et al. Risk factors associated with keloid infections: a five-year retrospective study. Int Wound J. 2023 Aug;20(6):2215-23.[Abstract][Full Text]

            • 96. Delaleu J, Duverger L, Shourick J, et al. Suppurative keloids: a complication of severe keloid disease. Int J Dermatol. 2021 Nov;60(11):1392-6.[Abstract]

            • 97. Liu R, Xiao H, Wang R, et al. Risk factors associated with the progression from keloids to severe keloids. Chin Med J (Engl). 2022 Apr 5;135(7):828-36.[Abstract][Full Text]

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