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droxidopa
generic
Black Box Warnings .
Supine Hypertension
monitor supine BP prior to/during tx and more frequently if dose incr; elevate head of bed to decr. risk of supine HTN and when measuring BP; decr. dose or D/C tx if supine HTN not managed w/ elevated head of bed
Adult Dosing .
Dosage forms: CAP: 100 mg, 200 mg, 300 mg
neurogenic orthostatic hypotension, symptomatic
- [100-600 mg PO tid]
- Start: 100 mg PO tid, may incr. by 300 mg/day q24-48h; Max: 1800 mg/day; Info: for pts w/ primary autonomic failure, dopamine beta-hydroxylase deficiency, and non-diabetic autonomic neuropathy; give consistently w/ or w/o food; give last dose >3h prior to bedtime
renal dosing
- [see below]
- CrCl >30: no adjustment; CrCl <30: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.